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Anyone Cycling Gleevec?

CML cycling off and on

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#1 roamingdoc83


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Posted 30 January 2016 - 01:16 PM

Anyone Cycling their use of Gleevec?

I read recently that a few studies were being done with "one month on, one month off" use of Gleevec?



#2 r06ue1


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Posted 01 February 2016 - 07:49 AM

I would never do that, reduced dosage or stop altogether would be my preference.

08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%



Taking Imatinib 400 mg

#3 roamingdoc83


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Posted 01 February 2016 - 08:31 AM

Intermittent -  http://www.nature.co...bcj201575a.html


I was 'off' completely for 19 months but it was not successful. Side effects for 'me' on the intermittent are greatly reduced during the off period however 'when on', while no more severe than normal, it is perhaps comparitively more noticed.

Need to do a BCR but cannot afford it right now. Just wondering if anyone had seen this report (there are indeed several such studies).





#4 scuba


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Posted 01 February 2016 - 10:28 AM

It is noteworthy that the same number - 50% - achieved success on the intermittent strategy (one month on - one month off) as those who stopped completely after 2 years PCRU.


The concept of "minimum effective therapy" is interesting as another tool to manage side effects. For 50% of patients who are not PCRU, but have low residual disease measureable (MMR), this approach has merit. This is especially true for older patients who have other health issues to manage.


For those who have been PCRU for a very long time (i.e. Trey / Susan), but are reluctant to try complete cessation out of an abundance of caution, one month on one month off might be a way to "wean" yourself off Gleevec and gain confidence you have beaten CML.... one month on one month off, one month on ... two  months off ... one month on, three months off.

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein


Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.


2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"

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