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Do we know what causes chronic myeloid leukemia?

CML Causes

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#41 scuba

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Posted 03 March 2016 - 01:36 PM

As you say Dootch - it's bad timing. An event that triggers a DNA mutation (Philadelphia chromosome / CML) coupled with a weakened immune system for other reasons. I would also add - bombardment. By this I mean the creation of so many cancer cells at one time (as from a radiation event whether bomb made or medical (i.e. cat scans)) that the body is unable to dismember them all because they developed a micro T-cell environment to save them - keep them growing.

 

In my own case, I am convinced my trigger were a series of cat scans I had a few years prior to CML diagnosis. I later learned the cat scan device was not properly calibrated and was emitting high dose radiation. As it is a normal cat scan emits 70 times the radiation of an x-ray. Think about that .... 70 times:

 

http://www.usatoday....ncerns/2005729/

 

I had five of these taken (when none were needed ... it could have been avoided).

 

Cat scans are dangerous. I will never have one again. As it is I am dealing with the aftermath of this massive radiation bombardment. And low vitamin D to boot - no wonder I developed CML.


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#42 rcase13

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Posted 03 March 2016 - 02:49 PM

Scuba that sounds like a law suit. You should get Trump involved!


10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg

 

Cancer Sucks!


#43 scuba

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Posted 03 March 2016 - 02:59 PM

Scuba that sounds like a law suit. You should get Trump involved!

 

Trump? whose Trump ... never heard of the guy.

 

(actually - when you sign the forms, it informs you that cat scans have risk and that some % of people develop cancer. Apparently I took the risk.)


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#44 survenant

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Posted 04 March 2016 - 11:36 PM

Could sitting next to a laser printer make you sick?

Warning: Laser Printers Could Be a Health Hazard

Office printers emit hazardous particles: CBC special report



#45 ShellyD

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Posted 31 March 2016 - 07:47 PM

I blamed the radiation pill I tooked for my hyper thyroid

#46 Denys

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Posted 02 April 2016 - 01:48 PM

I worked on chemical tankers, carriage of certain type of goods on this type of vessels bring high risk to get leukemia, but I was lucky I did not work with toxic cargo, mostly we took sunflower oil, palm sometimes. now I'm just have CML, and even have no idea why, all my life I try to avoid all toxic things even not use air freshener :) and dishwasher detergent, breathing with fresh sea air. So what were wrong? I believe nothing - it just a way of my (our) life and I (we) need continue living with out thinking why and looking back - future is our aim

#47 mikefromillinois

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Posted 22 April 2016 - 11:53 AM

Written by a Cleveland Clinic Leukemia doc:

 

http://well.blogs.ny...times&smtyp=cur



#48 r06ue1

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Posted 22 April 2016 - 12:00 PM

Good article, thanks mikefromillinois.  

 

I believe that a majority of these leukemia's is being caused by what we have done to our environment (nuclear, chemical) and the insane things they allow to be put in our food and drinks (Benzene).  Perhaps it doesn't happen in one single dose, but over time they build up and the odds of you avoiding it go down.  Look at all of the children getting leukemia?  Not hereditary.  


08/2015 Initial PCR: 66.392%

12/2015 PCR: 1.573%

03/2016 PCR: 0.153%

06/2016 PCR: 0.070%

09/2016 PCR: 0.052%

12/2016 PCR: 0.036%

03/2017 PCR: 0.029%

06/2017 PCR: 0.028%

09/2017 PCR: 0.025%

12/2017 PCR: 0.018%

 

 

Taking Imatinib 400 mg


#49 tiredblood

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Posted 23 April 2016 - 11:14 PM

Two of my theories of my circumstances coming together are exposure to acetone and electrical shock.  Of course, age is now considered a risk factor for development of cancer.



#50 Buzzm1

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Posted 24 April 2016 - 12:05 AM

Two of my theories of my circumstances coming together are exposure to acetone and electrical shock.  Of course, age is now considered a risk factor for development of cancer.

Makes sense to me; I had a gallon can of paint remover rupture in a back room storage area behind my attached garage a few years before I was diagnosed; the fumes badly corroded exposed metal in the surrounding area before I discovered it; my bedroom is above the garage and storage area.  That back room housed a Wurlitzer pipe organ with the pipes running up into the second story before I bought the home.  


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#51 tiredblood

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Posted 25 April 2016 - 11:10 PM

I was printing a lot while in school to a printer we have that was by my son's computer. I didn't realize how strong the smell was from printing until he told me and I observed it for myself.  I could certainly see this being hazardous to one's health.

 

I was at a department store the other day. The cashier told me she had developed cancer in her sinuses from paper dust exposure at a previous job. She had surgery, chemo, and had recovered from it. Now, she has a NHL diagnosis. Anyway, she sure went through a tough time as a result of her career.







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