5 replies to this topic

[LPJohn]

What is the percentage of folks that move from the Chronic Phase into the Advanced stages and are there certain characteristic of why folks progress on?

 

Thanks,

 

LPJohn

[Trey]

Only a couple percent advance from Chronic to Accelerated Phase after starting TKI drugs.  Most advancement happens before starting TKI drugs, which is why early diagnosis is better.  Poor response to all TKI drugs is the main reason for disease progression.

[LPJohn]

Thanks, I have not read any conclusive data but figured folks like Trey would have an idea. One web site indicate 2/3 move from Chronic phase to advance. I am a very very slow responder almost four years in I now tolerate 60 mg of Sprycel and at 4.00 PCR. A true snail but Dr. Talpaz calls it a success story. Just glad to be alive.

 

Thanks Again,

 

LPJohn

[CallMeLucky]

If 2/3 of cml patients progressed to advanced stage one would have to question the overall survival rate and progression free statistics for cml in general which are well over 80% and closer to 90% range.

2/3 of cml patients do not progress to advanced phase

Slow and steady can be successful
Good luck

[scuba]

Only a couple percent advance from Chronic to Accelerated Phase after starting TKI drugs.  Most advancement happens before starting TKI drugs, which is why early diagnosis is better.  Poor response to all TKI drugs is the main reason for disease progression.

 

... and lack of compliance (side effect related or other).

[Antilogical]

Thanks, I have not read any conclusive data but figured folks like Trey would have an idea. One web site indicate 2/3 move from Chronic phase to advance. I am a very very slow responder almost four years in I now tolerate 60 mg of Sprycel and at 4.00 PCR. A true snail but Dr. Talpaz calls it a success story. Just glad to be alive.

 

Thanks Again,

 

LPJohn

 

The web is a tangled mess where information lurks forever - even old, outdated stuff.  Medical treatments for many diseases - CML included - have improved dramatically over the last decade or so, so check the dates on the web pages you're reading.  The stats you read are ancient history....