
Abnormal liaise results..stopping Tasigna
#1
Posted 29 December 2015 - 04:28 PM
#2
Posted 29 December 2015 - 07:19 PM
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
Cancer Sucks!
#3
Posted 29 December 2015 - 07:36 PM
#4
Posted 29 December 2015 - 09:08 PM
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
Cancer Sucks!
#5
Posted 30 December 2015 - 02:24 PM
It usually means the TKI (especially Tasigna) is messing with the pancreas a bit. If you also have abdominal pain (sometimes from the back) then it may be bad enough to take a drug break. If it is just high, it may just be TKI drug induced issue. These tests assume there are no outside influences when they determine what is "normal". So overall it depends on the level of the enzymes, and whether there are also other symptoms. This usually resolves itself over time, maybe sometimes with a short drug break.
http://www.healthlin...tests#Overview1
#6
Posted 30 December 2015 - 03:19 PM
#7
Posted 03 January 2016 - 11:18 AM
#8
Posted 03 January 2016 - 10:37 PM
Left flank pain is probably just the spleen still healing. It can give off pain for a long time. The CML injures it and it takes quite a while to heal.
#9
Posted 04 January 2016 - 02:14 AM
#10
Posted 04 January 2016 - 11:07 AM
#11
Posted 05 January 2016 - 12:35 PM
I have had the same with regards to Lipase which is a non-specific marker of Pancreatic inflammation in addition to being an enzyme for fat metabolism. The key value is your blood glucose along with your Lipids and cholesterol.Tasigna has been associated with raising all three leading it to be a potential risk factor in development of vascular occlusive disease. For those reasons, I was switched to Gleevec (day #2 today and doing OK)
http://www.ncbi.nlm....pubmed/23459450
http://www.ncbi.nlm....pubmed/24658819
#12
Posted 05 January 2016 - 01:37 PM
#13
Posted 07 January 2016 - 07:21 PM
#14
Posted 07 January 2016 - 08:15 PM
Diagnosed June 2014. WBC 34.6 and Platelets 710 at diagnosis. Bone Marrow Biopsy pre-op diagnosis: Leukocytosis. Post-op diagnosis: the same, Leukocytosis. No increase in blasts <1%. Quantitative BCR/ABL testing and formal chromosome analyses confirmed CML diagnosis.<p>Supplemental Report: Abnormal BCR/ABL1 FISH result t(9;22). Molecular test for BCR/ABL1 fusion transcript by RT-PCR positive for BCR/ABL1 transcripts, b3a2 at 133.561% and b2a2 at 0.001% and ela2 at 0.001%. Followup monitoring showed negative for ela2. BCRABL1 was 148.007 at diagnosis. Started Sprycel 100 mgm and blood work was normal at 3 weeks. MMR at 3 months: 10/4/14 was 0.106. Stayed in that range with one dip to 0.04 once and back to 0.1 range. Oct. 2015, BCRABL1 was not detected, following with 0.0126, 0.0092, <0.0069, 0.0000, <0.0069, 0.0000. Now on 70 mgm of Sprycel. Continuation of PCR test results: 07/07/2017, 0.0000%, now on 50 mgm of Sprycel, PCR 9/12/17 0.0074%, PCR 11/3/17 0.0000%, PCR 1/17/2018 0.0000%
#15
Posted 07 January 2016 - 08:22 PM
Diagnosed June 2014. WBC 34.6 and Platelets 710 at diagnosis. Bone Marrow Biopsy pre-op diagnosis: Leukocytosis. Post-op diagnosis: the same, Leukocytosis. No increase in blasts <1%. Quantitative BCR/ABL testing and formal chromosome analyses confirmed CML diagnosis.<p>Supplemental Report: Abnormal BCR/ABL1 FISH result t(9;22). Molecular test for BCR/ABL1 fusion transcript by RT-PCR positive for BCR/ABL1 transcripts, b3a2 at 133.561% and b2a2 at 0.001% and ela2 at 0.001%. Followup monitoring showed negative for ela2. BCRABL1 was 148.007 at diagnosis. Started Sprycel 100 mgm and blood work was normal at 3 weeks. MMR at 3 months: 10/4/14 was 0.106. Stayed in that range with one dip to 0.04 once and back to 0.1 range. Oct. 2015, BCRABL1 was not detected, following with 0.0126, 0.0092, <0.0069, 0.0000, <0.0069, 0.0000. Now on 70 mgm of Sprycel. Continuation of PCR test results: 07/07/2017, 0.0000%, now on 50 mgm of Sprycel, PCR 9/12/17 0.0074%, PCR 11/3/17 0.0000%, PCR 1/17/2018 0.0000%
#16
Posted 07 January 2016 - 09:29 PM
#17
Posted 08 January 2016 - 02:27 PM
Because this book was written by a doctor, she uses terminolgy like "nervous illness". I have found that the things shared are helpful and it doesn't mean someone has to have a diagnosable anxiety issue to benefit from the book. We all know that a cancer diagnosis can create anxiety for anyone whether they have had anxiety before or not! Anyway, if you decide to read it, hope it helps. It was written years ago but the main principles are still good.
Diagnosed June 2014. WBC 34.6 and Platelets 710 at diagnosis. Bone Marrow Biopsy pre-op diagnosis: Leukocytosis. Post-op diagnosis: the same, Leukocytosis. No increase in blasts <1%. Quantitative BCR/ABL testing and formal chromosome analyses confirmed CML diagnosis.<p>Supplemental Report: Abnormal BCR/ABL1 FISH result t(9;22). Molecular test for BCR/ABL1 fusion transcript by RT-PCR positive for BCR/ABL1 transcripts, b3a2 at 133.561% and b2a2 at 0.001% and ela2 at 0.001%. Followup monitoring showed negative for ela2. BCRABL1 was 148.007 at diagnosis. Started Sprycel 100 mgm and blood work was normal at 3 weeks. MMR at 3 months: 10/4/14 was 0.106. Stayed in that range with one dip to 0.04 once and back to 0.1 range. Oct. 2015, BCRABL1 was not detected, following with 0.0126, 0.0092, <0.0069, 0.0000, <0.0069, 0.0000. Now on 70 mgm of Sprycel. Continuation of PCR test results: 07/07/2017, 0.0000%, now on 50 mgm of Sprycel, PCR 9/12/17 0.0074%, PCR 11/3/17 0.0000%, PCR 1/17/2018 0.0000%
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