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Does TKI Usage Cause an Increase in Serum Free Light Chains?

Started by mdszj , Dec 18 2015 07:47 PM

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3 replies to this topic

#1 mdszj

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Posted 18 December 2015 - 07:47 PM

All

Am wondering if anyone knows whether using a TKI can cause an increase in their serum Free Light Chains (FLC). These are immunoglobulin compounds that are produced in the body. FLC levels that are too high can indicate the presence of plasma cell disorders such as multiple myeloma, its precursor conditions, and other plasma cell issues. I know in cml they dont usually test for these. Turns out that I have a high level of one of these FLCs which gives me a precursor condition for myeloma and puts me at risk for developing myeloma in the future.

From looking at my lab results it appears that my FLCs started to increase after I started Sprycel. So I am wondering if the fix could be as easy as reducing my Sprycel dosage. But I am guessing that is way too easy, however it does seem to be quite a coincidence.

On the good side - I just picked up my first batch of 80 mg Sprycel today after being on 100 mg since I was dx in July 2012. So maybe my next blood draw will provide some info on my question. In the meantime any info is appreciated on this subject.

dx cml 7/2012; 100 mg sprycel; splenectomy 9/2012; reached prcu 10/2013; dx smoldering myeloma 1/2015; 80 mg sprycel 12/2015; 50 mg sprycel 7/13/16; discontinued sprycel 11/15/16

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#2 Buzzm1

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LocationSilicon Valley

Posted 18 December 2015 - 08:11 PM

On the good side - I just picked up my first batch of 80 mg Sprycel today after being on 100 mg since I was dx in July 2012. So maybe my next blood draw will provide some info on my question. In the meantime any info is appreciated on this subject.

what is your PCR mdszj? and your PCR history ... 80mg is hopefully the first of many reductions to quickly follow

wishing you continued success

For the benefit of yourself and others please add your CML history into your Signature

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.

Cumulative Gleevec dosage estimated at 830 grams

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.

Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt

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#3 mdszj

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Posted 18 December 2015 - 09:32 PM

buzz

I hit pcru in Oct 2013, about 15 months after being dx, and have been pcru since, with the exception of a blip above detectable last Oct. Hopefully there is plenty of room for me to reduce my dosage. I will just have to keep bugging my hemo to reduce further.

dx cml 7/2012; 100 mg sprycel; splenectomy 9/2012; reached prcu 10/2013; dx smoldering myeloma 1/2015; 80 mg sprycel 12/2015; 50 mg sprycel 7/13/16; discontinued sprycel 11/15/16

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#4 Trey

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LocationSan Antonio, Texas

Posted 18 December 2015 - 10:24 PM

Have not seen anything related to TKI drugs. More likely it is an inflammatory or autoimmune issue, type 2 diabetes onset, connective tissue damage, or something else not quite as dramatic. But TKI drugs might also be the cause.