Diagnosed 10 yrs ago. Gleevec (poor response after 2 yrs) Sprycel (pleural effusions) Tasigna (diabetes) Bosulif (4 months of severe diarrhea) Had to stop each TKI after 2 + yrs; Best response has been with Bosulif, PCR undetectable but not negative. When I switched from Tasigna to Bosulif I was off TKI for 3 month. PCR rapidly increased so I know I am not a candidate for stopping.
Oncologist is suggesting I go back to Gleevec. Is that my only option? Since my diagnosis I have had many ups and downs with discouragement over side effects but for the first time I feel fear. There was always "the next new TKI out there" but now I don't know of any. I also have developed aortic valve stenosis which will require surgery some time soon so don't want to take anything that will make that worse.
Any suggestions??? Onc wants me to start Gleevec after colonoscopy, endoscopy, ultra sound, liver tests all next week. Onc is always looking out for met of breast cancer.