6 replies to this topic

[survenant]

See Combination of Inecalcitol with tyrosine kinase inhibitor 

[kat73]

Interesting!  Anything to get those higher-up suckers out of their niche and kill 'em dead.

[Billie Murawski]

HuH?

[rcase13]

Found the following:

"Inecalcitol  (ICC) is a vitamin D3 analog exerting antiproliferative effects in several types of cancer cells"

 

Looks like there was a phase two trial this past January:

http://www.lspvc.com...d-leukemia.html

 

It also shows some improvement in Psoriasis. I have both Psoriasis and CML. So any news is good news! Hopefully these research teams are getting the money they need.

[Trey]

Seems like they say it helps with lymphoid (CLL) leukemia by reducing lymphoid cell counts, and then says it helps with myeloid (CML) leukemia which does not need to reduce lymphoid cells.  Overall I found their explanations about CML unconvincing.

 

If people want to say vitamins are useful, then fine.  I have taken them most of my life.  But health nuts and homeless people who eat only Slim Jims washed down with Thunderbird get CML at the same rate.

 

The ASH Poster Session abstract linked above in the first post was written by someone who is employed by the company trying to "sell" this concept.  That needs to be taken into consideration.

[rcase13]

Hmm that is eerily weird. I use to love eating a Slim Jim with my Makers Mark.

Now I have CML and have given both up

[scuba]

Seems like they say it helps with lymphoid (CLL) leukemia by reducing lymphoid cell counts, and then says it helps with myeloid (CML) leukemia which does not need to reduce lymphoid cells.  Overall I found their explanations about CML unconvincing.

 

If people want to say vitamins are useful, then fine.  I have taken them most of my life.  But health nuts and homeless people who eat only Slim Jims washed down with Thunderbird get CML at the same rate.

 

The ASH Poster Session abstract linked above in the first post was written by someone who is employed by the company trying to "sell" this concept.  That needs to be taken into consideration.

 

The lead authors of this poster session are from Inserm - French institute of health and University in Caen. Hardly from company's trying to sell "concept". Not until you get to the 4th author (who is clearly not the one doing the research - 4th authors don't write the papers or do the scientific work; they made a contribution (probably the compound) so they get their name on the paper). And what about all of the authors tied to big pharmaceutical company's trying to sell their "concepts"? 

 

Inecalcitol is intriguing for its anti-proliferation action and early indication to help drive differentiation of precursor cancer cells. It's not a vitamin but an analog to vitamin D3 (in terms of receptor action). The research they are doing is very interesting and worth consideration.