Posted 20 December 2015 - 11:40 AM
Talking about coffee, I drink a home-brewed 13+ cup coffee pot everyday, fresh ground San Francisco Bay French Roast (Costco) half regular, and half decaf, black ... sometimes a little more, sometimes a little less, ever since I retired 19+ years ago, and not much less before that; ... coffee drinking and computer work have always gone well together..
Just discovered, beginning with pressure on my left side over a year ago, kidney scare, and an ultrasound where no kidney problems were seen, and then a really bloated and sore irritated stomach, that I am likely flushing the digestive acid out of my stomach, through continual coffee drinking, creating digestive problems and discomfort, not at all unlike the discomfort that I went through in the months after beginning Gleevec almost six years ago, where I had to discontinue Gleevec for a few weeks to allow my stomach time to heal. It's a little more involved ... my first meal is at noon, when I take Metoprolol, a known stomach inflammatory ... the indigestion created set my stomach up for my evening after dinner Gleevec to compound the problem. I've stopped drinking coffee an hour, or two, before my noon meal, and wallah, the problem is subsiding. was taking a 1,000mg vitamin C with dinner to help create an acid environment to aid Gleevec absorption. Need a little more healing time before restarting the C, but my stomach is beginning to feel markedly better... now it's just the pressure on my left side ...
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt