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Bosulif

Started by Kellyb333 , Nov 24 2015 08:22 PM

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6 replies to this topic

#1 Kellyb333

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Posted 24 November 2015 - 08:22 PM

I starred Bosulif today, a little nervous but it's ok! I was on Tasigna but had too many interruptions due to Myelosuppression! Just checking to see how those who use this TKIare doing! Thank you

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#2 Tucker1

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Posted 24 November 2015 - 09:56 PM

I started it in July 500 mgs and it was rough for me. I had some liver toxicity so lowered dose but LFTs went higher so I had to stop. I was off for 6 weeks until liver numbers returned to near normal then started again on200 mgs same liver issues dose was cut to 100 mgs and LFTS leveled then climbed slowly for 5 weeks last week first decline in enzymes I really hope it is a trend. This is my 4th TKI so I hope it works. I go for a BCR next week I am anxious to know if i have kept my low numbers last PCR was .035. I feel OK on such a low dose but I have had rounds of pain once in both my hands for about a week and a half and this last week my back, neck have been really. Awful. What dose have you started with?

Dx: 11/2004 intermediate risk 400 mg Gleevec
11/2005 partial cytogenetic response PCR 6.3
Clinical trial Sprycel 50mg 2x daily 12/05
11/06 PCR weak positive
10/07 PCR undetectable
12/08 PCR .017
Recurring colitis from Sprycel
11/09 Tasigna PCR .0075 200 mg 2x daily
11/10 PCR .078 400 mg 2x daily
11/11PCR weak positive
2/12 PCR. .15 decrease 200 mg 2x (QT prolongation)
Dosage changes until 2015 QT recurrent PCR .004
7/15 bosulif 500 mg
Liver toxicity discontinued bosulif PCR .025
Restart bosulif 100mg
12/15 PCR .714
Increase bosulif slowly
2/16 PCR.5
5/16 PCR .000 bosuitinib 400mg
8/16 PCR .027 Bosuitinib 300mg
10/16 PCR .117 Bosuitinib 300mg
1/17 PCR .243 Bousitinib 300mg
4/17 PCR .403

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#3 Kellyb333

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Posted 24 November 2015 - 10:07 PM

My Dr has started me at 400mg, I did ask to start low and increase, but he wanted me to start at 400mg! Thank you

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#4 Buzzm1

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Posted 24 November 2015 - 10:07 PM

Kellyb333, here's an earlier thread on Bosutinib

http://community.lls...t/?hl=bosutinib

For the benefit of yourself and others please add your CML history into your Signature

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.

Cumulative Gleevec dosage estimated at 830 grams

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.

Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt

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#5 chriskuo

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Posted 25 November 2015 - 01:42 PM

Bosutinib is my 5th TKI in 5+ years and has had the best side-effect profile for me. I had a rough start at 500mg and after 2 weeks had to take a 6-week break. I restarted at 200mg for 6 weeks and then with things going well for 6 weeks, I moved up to 300mg.

This month, after 6 months at 300mg, I reached MMR for the first time in almost 6 years since DX.

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#6 Kellyb333

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Posted 25 November 2015 - 04:16 PM

Thank you, that is encouraging! I am 18 months in and have not gotten below 27%! Thank you

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#7 Melanie

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LocationArizona

Posted 26 November 2015 - 01:54 AM

It's been the miracle TKI for me. Only one I've been able to stay on long enough to reach CyCR. I also am cytopenic, so thankfully it's worked for me. Numbers still low, but been able to stay on 400 mg. Started at 100 and gradually built up. Can't manage 500, but 400 got me to CyCR first time ever. Pray it works for you! It also had the least side effects for me over all other TKI's.

Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)