Just wanted to share my story.
Dx'ed 2009 July.
Gleevec - 2009 - 2010 middle
Tasigna 800 mg - 2010 - 2014 March
Sprycel - 2014 March - Current
Over this period by my Systolic pressure between my two arms were different by about 20 points. I was asked to do a comprehensive Cardio analysis by my oncologist.
They did a Carotid scan and found my Carotid blocked about 20% atherosclerosis. Also some percent blockage is found in the artery branching into right hand that could explain the change in blood pressure. I am a non-smoker, social drinker (very rarely), vegetarian and exercise at 3-4 times a week.
My doctor thinks TKI's over period especially Tasigna has been implicated to cause this. There is obviously no proof but it is now added to the warning label so long term usage do result in progressive atherosclerosis and hence require constant monitoring and correctional treatment in certain cases.
Now I am being put on baby aspirin and possibly statins based on my lipid profile tests.
Wanted to share this so other can benefit from my experience. If you are using Tasigna for many years, you may want to consider asking your oncologist about further tests depending on your situation.
Any thoughts or feedback please share with me.