I am among those experiencing what I hear is called TKI withdrawal syndrome after stopping the TKI (in my case for the purpose of getting a more complete diagnosis from BMB). Remembering the aches and pains that occurred during the first few weeks of TKI therapy, and now, the aches and pains associated with cessation, I ponder whether titrating up the dose at initiation of therapy, or tapering the TKI dose down with cessation would be a better practice, rather than initiating therapy at full dose or cessation cold turkey. Just curious about other's thoughts on titrating/tapering dosage.
TKI cessation aches and pains- aside from another thread
Started by
tiredblood
, Nov 21 2015 11:29 PM
1 reply to this topic
#2
Gail's
-
- Members
-
- 634 posts
Advanced Member
Posted 22 November 2015 - 03:09 AM
I gather stopping cold turkey is used most for severe side effects of the TKI. And tapering for dose reduction once at pcr. Not completely sure, just an impression.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
