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Slow responder Sprycel PCRU PCR results test results CCyR PPI

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#1 August1


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Posted 17 November 2015 - 08:49 AM

Hi everyone,

I was diagnosed in August 2012. My WBC was 240,000. I started on Gleevac for the first year and switched to 100mg Sprycel due to some minor side effects. 


I have historically been a "slow and steady" responder as it took me about 14 months to reach CCyR and a little over 2 years to reach MMR. 


Happy to say I've gotten my latest results and have now maintained PCRU for 7 months. This time around I was sure to get the draw done early in the week and had the lab ensure the sample was picked up on the same day. 


7/13 - 1.062% - Switch to Sprycel

10/13 - 0.9272% - CCyR FISH 

11/13 - 0.608% - switched to 6 month testing cycle by Oncologist

3/14 - 0.394%

9/14 - 0.208% - started taking meds in morning (I take a PPI at night for reflux)

4/15 - 0.000% - PCRU

11/15 - 0.000% - PCRU


Just thought I would post in case there are others out there with similar experience.


Take Care!

#2 Trey


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Posted 17 November 2015 - 10:52 AM

Hopefully those two PCRU in a row shows the steep drop from .208% to PCRU was real.

#3 rcase13


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Posted 17 November 2015 - 01:38 PM

Is every 6 months a normal testing regime after a certain time? I am every 3 months.

Your results are fantastic. I hope to get there some day.

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg


Cancer Sucks!

#4 August1


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Posted 17 November 2015 - 03:01 PM

Thanks, rcase. I'm not sure, but once I reached CCyR my oncologist switched me to having a CMP/CBC every three months and a PCR test every 6 months. For me it is helpful as I'm not worrying about the PCR results every three months. 


Trey, I hope so as well. I was really surprised when I saw the drop from 0.208%. I figured there must have been some processing error. This time I had the draw done on a Tuesday and made sure they agreed to send the sample for processing same day. 


This latest result helps a lot but I wouldn't be shocked to see periodic blips in the future. My hope would be to maintain PCRU and then hopefully get to a dose reduction. That would be tremendous but I'll likely wait one or two more testing cycles to try..  

Also tagged with one or more of these keywords: Slow responder, Sprycel, PCRU, PCR results, test results, CCyR, PPI

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