3 replies to this topic

[mdszj]

Hi all

 

Was wondering if anybody takes Sprycel and Synthroid/levothyroxin (for hypothyroid), and if so, has your synthroid or levothyroxin dosage needed to increase since starting sprycel?  From what I can tell Sprycel (100 mg) seems to interfere with the synthroid/levo.  Since I was dx with cml in july 2012, my dosage of synthroid has gone up in the last couple years, from 25 or 50 ug initially to my present dose of 125 ug.  It is now stable so hopefully will not need to go up further. 

 

thx for any info

 

 

 

 

[Lisa Lisa]

I am on Sprycel 60 mg and Synthroid 50 Mcg. I am not on the generic Synthroid. I was dx w CML in late February 2015, and I have not had any drug interaction nor an increase in the Synthroid medication. My levels seem to be the same as before dx. I have heard of others having a different reaction and their needing to up their dose, but that is not the case with me.

[mlk210]

I was on Sprycel when I needed to start Synthroid (I do not take generic either). I had a total thyroidectomy two months after starting Sprycel 100mg. I take (2) 112mg of Synthroid and I also take Cytomel (straight t3) 5mg. I do separate them out from one another. I take my synthroid and cytomel in the morning and then Sprycel at 4pm. It took them a long time to find the dose that would keep me suppressed enough (they keep my level at .2 since I had thyroid cancer, so, I teeter on the edge of hyperthyroid), but I think that's common for it to take months to find someone's correct dose after a total thyroidectomy. My thyroid levels have stabilized in the last three months.

[kat73]

I've been taking levothyroxine since a subtotal thyroidectomy in 1979, both Synthroid and in later years the generic.  My levels are tested periodically and have not changed since 2009 when I started Gleevec and then Sprycel (last four years.)  Therefore, the levothyroxine dose has not changed either.