13 replies to this topic

[vbonsu9]

Dear Trey, dear all
I've just received my first Fish report after dx 3 months ago, and it reads:
'result is within normal limits (<1% of nuclei with BCR/ABL fusion).
Please what does this mean?
Regards
Victor

[R0f03l]

I believe That it's alright in BCR ABL.

 You have no values with numbers?

 

Hugs .

[Trey]

VB,

 

Fish is negative.  That is Complete Cytogenetic Response (CCyR).  Equivalent roughly to a 2 log reduction in PCR.  Next goal is Major Molecular response (MMR) which is a 3 log reduction in PCR or .1% PCR. 

 

Very good for only 3 months.  Congratulations.

[vbonsu9]

Many thanks for comments.

[vbonsu9]

Dear Trey, All
In addition to my Fish report, I have received the following:

BCR-ABL Rearrangement PCR, Blood:- Positive, 0.04

Kindly please tell me what it means.
Thanks.

[Trey]

Is this .04% ?  It must be a percentage to be useful.  If it is not clear, ask your Onc.

 

If it is a percentage, it would be MMR (3 log reduction) since you are better than .1% (also assuming your PCR uses International Standard).  So if the number is a percentage, and it is also International Standard, it is better than MMR.

[vbonsu9]

Hi Trey, i checked again and it's 0.04% international standards. What is MMR?
Thanks.

[Trey]

MMR means Major Molecular response (MMR) which is a 3 log reduction in PCR or .1% PCR. 

 

Achieving this in only 3 months is a very fast response.  Outstanding. 

[vbonsu9]

Thanks, Trey.

[vbonsu9]

Dear Trey
I had another test, I guess PCR, and the results read:
the expression level of BCR-ABL transcripts is equivalent to international standard 0.01% BCR-ABL ratio. This is most consistent with an extremely low level positive result.
Please what does this mean? I had similar test about 3 weeks before this and it was 0.04%. I have so far been dx 4 months and on 100mg spyrcel.

[Trey]

I think you are reading the standard information provided on the PCR test results sheet, and it does not mean your result was .1%.  As you said, your result was .04%, which is better than .1%. 

 

Again, you are doing much better than average.

[vbonsu9]

Hi Trey, the figure is 0.01% and not 0.1%

[CallMeLucky]

It sounds like you have two test results, one from last month, .04% and now one today .01%, showing a slightly further reduction. If that is the case then you are doing extremely well. Keep taking your meds and continue on with life.

[Trey]

Unless you provide an exact quote it is impossible for us to tell you what it means.