Hi Trey, hi All
I was diagnosed with CML 3 months ago. I am on Spyrcel 100mg. My WBC went down the normal range at a Point in time. But for about 6 weeks now, I have noticed that the WBC is moving up. My result this morning indicates that it is 7.16. Two weeks,ago it was 6.56. Is there something wrong?
Thanks
WBC upward trend
Started by
vbonsu9
, Oct 26 2015 11:02 AM
4 replies to this topic
#2
Buzzm1
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Posted 26 October 2015 - 12:19 PM
WBC normal is 3.5 - 12.5 K/uL
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
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#3
rcase13
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Posted 26 October 2015 - 12:24 PM
You will have to get use to results doing that. The test isn't that accurate.
But that does make me wonder at what PCR percent we will start to see elevated WBC.
But that does make me wonder at what PCR percent we will start to see elevated WBC.
10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)
01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg
Cancer Sucks!
#4
Trey
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Posted 26 October 2015 - 08:19 PM
WBC is not very useful for determining drug response status. Rely on your FISH and PCR tests to show how you are responding to drug therapy. Many have low counts on TKI drugs, but not all. We are all different.
At 3 months you should have another FISH and PCR. See what those show and report back to us.
#5
soundoff
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Posted 28 October 2015 - 01:43 AM
As usual Trey is 100% correct.
Forget about your CBC'S now your doing fine.
Your white blood is in normally range.
Forget about your CBC'S now your doing fine.
Your white blood is in normally range.
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