I received my lastest (October) PCR test result without any TKI for nine months. No change. Holding steady at PCR = 0.06% IS scale.
I started my cessation experiment last February when my PCR was undetected. PCR rose into detection but then fell back. It rose again and is now hovering at this level for a couple of months. I had expected relapse to be much faster than this if it is going to occur, but thankful I have had nine months of no Sprycel.
Because I am still below MMR, Dr. Cortes is fine with me going another month without Sprycel (20mg.). My experiment continues.
This next month will be definitive, however. If my PCR level remains the same, I will re-start low dose Sprycel anyway to test how quickly I can drop PCR back down again (one log drop). If I can do that, then I will pursue a pulse strategy of one week on - three weeks off. Although I had hoped I would be able to maintain low level residual at a fairly constant level without any TKI, I sense that I might have to "pulse" treat CML. Hit it to knock it down and then no drug (I do believe it is the Curcumin which is keeping CML expansion slowed - but not stopped as far as I can tell. I have one more month to see).
My bet with Trey was for one year. I'm almost there, let's see if I can keep this experiment going.