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Skin cancer with Tasigna

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#1 Floa7


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Posted 12 October 2015 - 05:44 PM

I went to my oncologist 6 weeks ago for 3 month check-up. She was talking about another one of her patients having sores who has CML and also on Tasigna. She was waiting for a phone call. I showed her two sores on my left leg and I was sent to a dermatologist. He did biopsies on both sores and they have come back malignant. Are these results of Tasigna? Anybody else have sores that won't heal? The sores are 1/2 inch and won't heal, they have a thick scar tissue around them.

I go back to the dermatologist on the 22 and have them removed.

1 2012 CML detected Started Gleevec 400 mg

In nov 2014 my pcr started to rise by Feb I stopped Gleevec and went onto

2 2015 Tasigna 600 mg/day

I have been PCRU for 2 years and stopped Tasigna 4 7 2017

5 8 2017 results 0.008

5 30 2017 results 0.028 

6 30 2017 results 0.3, I have restarted the Tasigna because it went above 0.1 


My son

11 2011 CML detected Started Gleevec 400 mg

He went 2 1/2 years on gleevec and lost PCRU

Started Sprycel went PCRU for 2 years and stopped the Sprycel, went back for 3 month checkup and PCR was 8.0

He went back onto Sprycel and now is PCRU again

3 16 2017 results 0.008

6 1 2017 results 0.002

#2 Pin


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Posted 13 October 2015 - 07:24 AM

Wow, I'm sorry to hear that :( What type of skin cancer is it? Will it be ok to remove?

From memory, I don't think the TKIs are associated with other cancers. But anecdotally, I do know others have had them from time to time. I think it's possible we may be more susceptible as our skin might before sensitive to things like the sun. But that's just a guess.

All the best xx Pin.

Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).

Commenced monthly testing when MR4.0 lost during 2012.


2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)

2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)

2015: <0.01, <0.01, <0.01, 0.013

2014: PCRU, <0.01, <0.01, <0.01, <0.01

2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01 

2012: <0.01, <0.01, 0.013, 0.032, 0.021

2011: 38.00, 12.00, 0.14

#3 Billie Murawski

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Posted 14 October 2015 - 12:54 AM

Flo, I"ve had so many skin cancers both squamus and basil cell, I had a melanoma in 2005 2 years before my cml dx. I just went to the dermatologist 2 weeks ago and she froze 6 areas and did 2 biopsies, I just got my call back today and the one biopsy was neg, but the one on my arm is precancerous so she is going to watch it close and I go in December and she will freeze that one so hopefully that will take care of that one. I don't think cml or tki's have anything to do with it, I was just an idiot who spent way to much time in the sun. The ones that I get look more like a pimple, or a very light white film over the sc. Just make sure you check your body often and if anything unusual shows up call your doc. Some times it can be like a small pimple that just won't go away. I have to go and get checked every 6 months.  Good luck Billie

#4 Melanie


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Posted 14 October 2015 - 10:17 AM

I've had a similar experience when I was on Tasigna and no one knew what it was. It was on my chin and as you describe Floa7, except they never took a biopsy. It eventually healed, but left a nasty scar on my chin about the size of a quarter. And Billie, like you, I never worried about the sun when I was younger and am paying for it now. I've had many basil cells removed plus other pre-cancerous bumps., I'm now on Bosulif and go to the dermatologist every two months to have things checked out. Just went and have over a dozen areas that she burned off before I said enough! We laugh and she says it's getting hard to tell now between all the age spots and the suspicious spots!

As a side note, she worked in cancer research at our University for years and she believes it's not so much the TKI's as the weaker immune system that's causing the skin issues. She's especially concerned about any warts, because they're actually a virus and our immune systems have enough to fight that they don't need anything else to worry about. I have had several removed.

I also have a friend that had a transplant and he has to go to dermatologist every 3 weeks. In his case it is the drugs. Interesting note though as part of pre- transplant preparation, he had to get clearance from his dermatologist that he had nothing going on with his skin. So, I think there's definitely a tie in with the immune system not being able to fight skin issues when there's a bigger problem going on.
Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

#5 cmljax


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Posted 11 January 2017 - 08:10 AM

I was dx in late September 2016 and started on Tasigna 300mg twice a day. I had three confirmed squamous cell skin cancers in the following 3 months plus an additional 20 some suspicious spots frozen by my dermatologist. I have never previously had skin cancer, only a few precancerous spots removed. She thinks this is being caused by the Tasigna and on December 14th she recommended I start Soriatane, but I declined after reviewing the side effects profile and decided to seek a second opinion. My oncologist does not know what s causing this and says there is no known link between Tasigna and any other form of cancer; my PCP thinks it is my compromised immune system from the CML and he suggested I defer on taking the Soriatane.


Since December 14th, I have a a significant decline in the number of suspicious spots, bumps etc, so I was beginning to think that the situation was improving. Yesterday I saw a dermatologist as Mayo. I showed her the only 3 suspicious spots, all on my left lower leg, that had developed since December 14. She suspects more cancer and biopsied all 3 sites.  She was ambivalent about Soriatane, but did offer an alternative with fewer side effects - Nicotinamide (also Niacinamide) 500mg twice a day,  which is a Vitamin B3 derivative.  I started that last night. An Australian study in 2015 showed statistically significant decline (23%) in non-melanoma skin cancers in group using Niacinamide versus placebo.


Dealing with the skin issues and CML is pretty tough, but I do not want to stop the Tasigna since I reached MMR in just 83 days!!  If these last 3 biopsies are positive I am going to contact Novartis (maker of Tasigna) directly).

Dx 9/26/16 WBC 28800; platelets 749; FISH 97% PCR 43%

Tasigna 600MG per day

October 2016                     PCR 22% IS

November 2016                 PCR 5.8% IS

December 2016                 PCR 0.1% IS  MMR!!

March 10, 2017                 PCR 0.006% IS  MR 4.22

Tasigna 450MG per day

April 5, 2017                      PCR <.003% IS

June 5, 2017                     PCR <.003% IS (dose reduction validated!!!)

Tasigna 300MG per day starting June 15, 2017

6-day drug break starting June 20, 2017 due to multiple AE's

July 24, 2017                     PCR <.003% IS

September 18, 2017          Negative, AKA PCRU

Tasigna 150mg per day starting 9/18/17

October 30, 2017               Negative

December 11, 2017           Negative

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