Yes, I'm an interloper from AML land. I have been very impressed with this group and especially by the knowledge here. It seems that there are true benefits of curcumin and CML management and I am curious if any here are aware of any benefits for AML in remission.
I am 29 months in remission with chemo only as a had a favorable sub-type Inversion 16 with no mutations-CKIT or FLT 3. I have dipped my toe in very tentatively taking only 1000mg daily-Super Curcumin with Bioperine from Ageless Cures. Any assistance would be greatly appreciated.
There is a great deal of research on Curcumin for Leukemia, in general, and AML specifically. Here is a link to a support site that discusses a patients use of Curcumin; http://www.dailystre...-treatments-aml
Readers on this forum know I am a very strong believer in Curcumin's effectiveness as an adjunct therapy in CML. I take 8 grams of Curcumin a day - most days. 1 gram as you are doing is insufficient due to the low absorption of Curcumin through digestion. I have been taking Curcumin in this way for years. I have not turned yellow.
Curcumin's role in its anti-cancer properties is in its down-regulating of key protein synthesis pathways needed for cancer proliferation. In addition - Cancer cells put out cytokines (proteins) that greatly increase the number of Regulatory T-cells (Tregs). Tregs in greater numbers suppress other T-cells (such as NK cells) from activating and attacking cancer cells. This regulation is quite necessary to prevent our immune system from attacking "self". Cancer cells cleverly use this mechanism to shut down our own immune systems ability to kill cancer. It is the cancer cells way of telling the body's immune system "I am self - don't attack'. Curcumin helps keep cancer cells more exposed to immune attack by down-regulating signals that tell the cancer to proliferate and upregulating other T-cells to attack. Like many "phytochemicals" (plants) - Curcumin has properties which assist the body's natural homeostasis mechanisms.
Curcumin is no cure, but patients report in myeloma, AML and CML cases that expansion of their cancers have stopped.
In my own case, which was difficult in the early stages, my CML was brought under control only after I started taking Curcumin. In addition, I was able to reach significant remission on only a 1/5th the normal dose of the drug I was taking. And now I no longer take any drug and have been able to keep my status unchanged for the last 8 months.
Curcumin is a tool. I believe it helps and certainly doesn't hurt. It is not a replacement for FDA approved therapy used in the treatment of cancer. I don't recommend people throw away their cancer drugs and take Curcumin instead. That would be stupid.
Also - consider checking your vitamin D level. Vitamin D helps activate your iummune's system other T-cells ( vitamin D level was pitifully low prior to my diagnosis. I have since raised it and keep it at high normal now (65 ng/ml). Again - not a cure, just additional support to help fight a terrible disease.
Each of us has to decide what's best for them. Some follow their doctors advice religiously. I prefer to read, learn and apply what makes sense for me in addition to working with my doctor. What I do is not clinically scientific (i.e. FDA approved, double blind, large population studies), but there is a lot of research science being done with Curcumin that suggests it could work. That was enough for me to try. All the best.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"