It's been a while since I posted on this topic but I'm back talking about pregnancy and finally with some happy news.
As it's been so long some background:
dx Dec 2010 at 37. I'd been with my future husband for 16 months and were just about to start trying for children. Instead we did preservation ivf and got married before I started treatment. I responded well to gleevec (600 and then 800) and came off it as soon as I reached PCRU in early 2012 to try for a pregnancy. We tried to get pregnant, the CML came back quickly, ended up on interferon, suffered on interferon (some unusual side effects + it just sux), went into ovarian failure and basically that was that. I restarted TKIs, this time tasigna and did well, back to PCRU in 2013. I also stayed in ovarian failure/menopause.
But we didn't give up. We found a wonderful egg donor who did a cycle for us in 2014. We looked into surrogacy but as I continued to respond well we eventually went with me. In April (2015) I had been PCRU for 2 years with the exception of two 0.004 readings a year before. We stopped treatment for a two week washout before embyro transfer. The PCR on the day I stopped treatment was my first detected in a year (0.002) but we didn't get that result until after we found out I was pregnant first try. The start date for the pregnancy (the day my cycle would have started had it not been a donor ivf transfer) ended up being the day I stopped the TKI. The next PCR at 4 wks was PCRU but the one at 10 weeks was a big jump to 0.12. I started interferon alpha 2b at 16 weeks at which time my PCR was 4.2. The PCR at 19wks was essentially unchanged at 5.2, so hopefully not going up any more. I started the interferon at a v low dose and am still in the increasing phase. We are aiming for 25 MIU per week (pre-pregnancy surface area was ~ 1.7m^2), which I should get to in about 3 more weeks. I'm doing the injections 5 days on, 2 off. I'm also on clexane due to a previous dvt so I get to give myself 12 injections a week.
I am now 20.5 weeks and the 20wk scan this week showed a perfectly normal little one . We are still nervous, I had a bleed at 15 wks.
Other than constant nausea (morning sickness) I felt brilliant in the first trimester while off treatment... so much energy! The interferon has been hard and continues to be hard (I'm not working and there are many days when I barely function) but I haven't had any of the scary (neurological) side effects I had last time.
Our due date is early in the new year