I went a year with no nausea now it's been 18 months, and I get very bad nausea about once a week. It may be because of drinking wine the previous night.
Does anyone have any thoughts or solutions for this.
Thanks
Nausea and Gleevec
Started by
jmoorhou
, Sep 02 2015 10:57 AM
8 replies to this topic
#1
jmoorhou
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Posted 02 September 2015 - 10:57 AM
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis
#3
OhNanna
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Posted 03 September 2015 - 12:36 AM
I'm newly diagnosed and have only been on Gleevec for 2 months. I probably have nausea every day, it totally stinks! It seems most say the side effects taper off around 6 months, was that your experience also? (I don't drink any alcohol.). I did find a chewable tablet called Nauzene that seems to help!
#4
hannibellemo
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Posted 03 September 2015 - 06:06 AM
It's been several years since I've been on Gleevec but I remember a short period where I had been on it for about 6-7 months and all of a sudden I developed daily nausea. The only break I had from it was when I slept and when I ate. It lasted about 1 month and then disappeared. I stopped taking it at 9 months so I don't know if it would have been a reoccuring side effect. Never really felt like vomiting, just had a low grade nausea.
Hope yours goes away, too!
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
#5
Gail's
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Posted 03 September 2015 - 12:26 PM
My nausea has gone from all day every day to a couple of times per week. Those are miserable days but so much better than when I started. I'm sorry you're feeling bad again, jmoorhou. But I'm not surprised. This is a powerful drug and I honestly think we will probably always feel it in some way or another.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#6
RayT
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Posted 04 September 2015 - 08:23 PM
I had nausea issues early on but now usually take Gleevec (400mg) with just a glass of water before bedtime, usually about 1-2 hours after eating. I also am able to take 650mg of ferrous sulfate each day with no gastric upset. Go figure...
Lucky RE: nausea, not so lucky RE: fatigue, edema, muscle cramps. 
#7
jmoorhou
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Posted 08 September 2015 - 06:46 PM
FYI...it was the drinking, I stopped and no more nausea....
Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis
#8
Buzzm1
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Posted 08 September 2015 - 08:00 PM
glad you figured it out jmoorhou. on to bigger and better things.
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt
#9
OhNanna
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Posted 08 September 2015 - 11:23 PM
Glad you figured it out jmoorhou!
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