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Closer to a cure????


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#1 Widgeonus

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Posted 27 August 2015 - 11:57 AM

Researchers Discover How Myelogenous Leukaemia Stem Cells Obtain Their Nutrients

 

 

https://scicasts.com...heir-nutrients/



#2 rcase13

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Posted 27 August 2015 - 02:27 PM

Thanks for this... Starve the little bastards!!

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg

 

Cancer Sucks!


#3 Terran

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Posted 27 August 2015 - 09:50 PM

Sounds awesome.

#4 max1m

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Posted 28 August 2015 - 02:16 PM

This looks so promising!

Here is the link to the full publication http://www.nature.co...ncomms9039.html

Cefadroxil, the antibiotic mentioned in the article, is already FDA approved. I wonder how long it will take for clinical trials.



#5 TeddyB

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Posted 30 August 2015 - 10:28 AM

"It will open up a novel avenue for curative CML therapy." Dr. Naka explained."

 

Hmmm, interesting, thanks for sharing :)

 

Lets hope they make it to human trials.



#6 scuba

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Posted 30 August 2015 - 11:33 AM

Fascinating article - looks promising. One caution cited in the article, however:

 

"Indeed, administration of cefadroxil in the absence of a TKI appeared to accelerate disease development in CML-affected mice. Thus, any application of transporter inhibitors to CML patients must be carefully considered".

 

Getting the dose combination correct (as well as determining if it works in people) will be a key part of any clinical trial.

 

In my own case, since I no longer take Sprycel, taking cefadroxil by itself is likely to re-energize any latent CML as the research article points out. But I would consider going back on Sprycel and take cefadroxil together if it means CML oblivion can be achieved. 

 

We're getting closer ... just a matter of time. 


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#7 Tedsey

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Posted 30 August 2015 - 11:39 AM

Scuba,

 

Was there a link to the whole article?  I must have missed it.

 

Teds



#8 Tedsey

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Posted 30 August 2015 - 11:41 AM

Ooops!  Max1m, thanks for posting.  I missed it.



#9 scuba

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Posted 30 August 2015 - 11:43 AM

This looks so promising!

Here is the link to the full publication http://www.nature.co...ncomms9039.html

Cefadroxil, the antibiotic mentioned in the article, is already FDA approved. I wonder how long it will take for clinical trials.

 

Teds,

 

Max1m provided the link - see above in the quote or in the thread.


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#10 TeddyB

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Posted 30 August 2015 - 12:33 PM

Fascinating article - looks promising. One caution cited in the article, however:

 

"Indeed, administration of cefadroxil in the absence of a TKI appeared to accelerate disease development in CML-affected mice. Thus, any application of transporter inhibitors to CML patients must be carefully considered".

 

Getting the dose combination correct (as well as determining if it works in people) will be a key part of any clinical trial.

 

In my own case, since I no longer take Sprycel, taking cefadroxil by itself is likely to re-energize any latent CML as the research article points out. But I would consider going back on Sprycel and take cefadroxil together if it means CML oblivion can be achieved. 

 

We're getting closer ... just a matter of time. 

 

So CML Stemcells get aggregated and comes out of hiding, and if there is no TKI in the bloodstream to kill it off, then there would be big trouble? Makes sense.



#11 Trey

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Posted 30 August 2015 - 01:48 PM

Another piece of the complex puzzle, so good research information.  But many questions and issues remain.  And mouse blood cells and mouse "CML" are not exactly like human cells and CML, which must be remembered.

 

Not sure I understand why TKI drugs need to be involved since this is a CML stem cell starvation issue, and TKI drugs are also said to be ineffective against CML stem cells, so the interaction with TKI drugs is not known.  And whether the originating CML stem cell acts like these lower level LT-LSCs which were targeted is unknown.  The expanded article says that these targeted dipeptides are also found in a specific sub-group of normal blood cells, so not sure why they ignored this issue since that means the drugs could possibly harm some types of normal blood cells.

 

No clinical trials could be done unless a more specific SMAD3 inhibitor is developed.  Long term use of antibiotics such as the one used in this study (cefadroxil) is not FDA approved and likely harmful to humans when used for such an extended period of time.  Many of us have taken antibiotics during our TKI treatment and likely none of us saw any difference after taking them for the normal short duration allowed for such drugs. 

 

But all pieces of the puzzle are important for the eventual cure to be developed.  They just are not usually effective in isolation.



#12 gerry

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Posted 30 August 2015 - 05:49 PM

I'm still curious as to how you know when all CML has been eradicated, including the stem cells?



#13 Trey

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Posted 30 August 2015 - 10:11 PM

Not possible to know for certain.  But that is true of virtually all cancers and many other illnesses. 






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