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The LAST Study


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#1 gerry

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Posted 17 August 2015 - 05:48 AM

http://www.pm360onli...fe-after-tkis/ 

 

The LAST Study: CML trial examines life after TKIs

BY MARY JO DALES in Oncology on August 14th, 2015

 

 

FROM CLINICALTRIALS.GOV

In the last 12 months, 12 actively recruiting trials examining chronic myeloid leukemia have been listed at clinicaltrials.gov.

Most of these trials examine the efficacy of various tyrosine kinase inhibitors (TKIs), but one trial called The LAST Study seeks to determine what happens to patients after TKIs - those patients who have undetectable BCR-ABL by polymerase chain reaction (PCR) test for at least 2 years. The goal of this study is to improve decision making for TKI discontinuation, and patients will be closely monitored for molecular recurrence, testing them monthly for 6 months, then every other month for 24 months, and quarterly until 36 months. Patients who have molecular chronic myelogenous leukemia recurrence will restart TKIs and will continue to be monitored for disease status and patient-reported health status.

 



#2 Trey

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Posted 17 August 2015 - 08:45 AM

Interesting to note that "pregnant or lactating women are excluded" from cessation trials.  Since they are not taking a TKI drug during this trial, one wonders why.  Is it because women produce extra interferon while pregnant?  But that is not true for the lactaters.  Is "lactaters" a word?  (Billie: I am not saying this is someone who needs to go buy potatoes).



#3 pammartin

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Posted 17 August 2015 - 05:49 PM

Lactaters.  I think I just peed my pants.



#4 Antilogical

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Posted 17 August 2015 - 05:58 PM

Lactaters.  I read the last sentence twice - slowly.  Then it dawned on me and I nearly spit out my wine.


Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.

Rx: 03/2012-Gleevec400.  Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).

Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.


#5 Billie Murawski

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Posted 18 August 2015 - 09:30 PM

Thanks for clearing that up for me Trey, I'd hate to have to go to the store this late at night. But I do always have tater tits on hand all the time ya know just in case!



#6 Trey

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Posted 19 August 2015 - 09:21 AM

I didn't realize female taters had those.  Do they make something from male taters?



#7 pammartin

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Posted 19 August 2015 - 09:30 AM

I really need to stop reading this with a beverage in hand.



#8 Billie Murawski

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Posted 19 August 2015 - 03:20 PM

Trey, Yeah male taters make tater tots!



#9 Trey

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Posted 19 August 2015 - 03:51 PM

See Billie, you haven't lost your touch. 



#10 Billie Murawski

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Posted 19 August 2015 - 04:23 PM

Trey,  I guess I just need more practice :wub:






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