Does anybody split their daily dose of Sprycel e.g. 50mg 2x/day? Did it improve any side effects? Any negative consequences re. PCR? Thanks in advance.
Sprycel - splitting dosage
Posted 13 August 2015 - 07:52 AM
<.01 IS 10/16 hopkins didn't report actual percentage
.007 IS 6/2017
<.01 12/2017 again no actual percentage but didn't see the report myself yet
Posted 13 August 2015 - 02:03 PM
Studies of the dose splitting issue showed that splitting Sprycel dosage actually increased side effects. This is the opposite of the other drugs. I assume this is because the half-life of Sprycel in the body is only 5 hours while the half-life of Gleevec and Tasigna are about 16 - 18 hours. Having said that, studies do not always show how an individual would be affected. So it would be worth a try.
By the way, the original dosing schedule for Sprycel was twice daily.
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