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Sprycel - splitting dosage

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#1 blueheron


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Posted 13 August 2015 - 07:52 AM

Does anybody split their daily dose of Sprycel e.g. 50mg 2x/day? Did it improve any side effects? Any negative consequences re. PCR? Thanks in advance.

DX 6/2013

Sprycel 100mg

CCR 3/2015

MMR 2/2016

<.01 IS 10/16 hopkins didn't report actual percentage

.007 IS 6/2017

<.01 12/2017 again no actual percentage but didn't see the report myself yet

#2 Trey


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Posted 13 August 2015 - 02:03 PM

Studies of the dose splitting issue showed that splitting Sprycel dosage actually increased side effects.  This is the opposite of the other drugs.  I assume this is because the half-life of Sprycel in the body is only 5 hours while the half-life of Gleevec and Tasigna are about 16 - 18 hours.  Having said that, studies do not always show how an individual would be affected.  So it would be worth a try.


By the way, the original dosing schedule for Sprycel was twice daily.



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