Jump to content


Liver Damage

  • Please log in to reply
1 reply to this topic

#1 Sneezy12


    Advanced Member

  • Members
  • PipPipPip
  • 67 posts
  • LocationMinnesota

Posted 05 August 2015 - 06:08 AM

iiKiJ Pediatr Hematol Oncol. 2015 Aug;37(6):e368-71. doi: 10.1097/MPH.0000000000000337.
Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.
Suzuki R1, Kobayashi C, Sakai A, Fukushima H, Tagawa M, Satomi K, Nanmoku T, Sumazaki R, Fukushima T.
Author information
Imatinib mesylate has dramatically improved the outcome of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL) and is now included as first-line therapy. Uncommon adverse effects of this drug for pediatric use, however, are largely unknown. We report the first case of a 9-year-old child who developed severe acute hepatitis with grade 4 transaminases and bilirubin elevation during imatinib treatment for Ph ALL. Liver biopsy showed extensive lobular and pericentral necrosis of hepatocytes. Liver function recovered after discontinuing imatinib with a 4-week prednisolone. Extensive hepatic necrosis should be considered not only in adults but also in children under imatinib administration.
PMID: 25929609 [PubMed - in process]
Share on FacebookShare on TwitterShare on Google+
LinkOut - more resources
PubMed Commons home
PubMed Commons

How to join PubMed Commons

#2 Trey


    Advanced Member

  • PS Beta Group
  • PipPipPip
  • 1,705 posts
  • LocationSan Antonio, Texas

Posted 05 August 2015 - 09:16 AM

A second option is she may have contracted the hepatitis virus.



Edited by Trey, 05 August 2015 - 09:17 AM.

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users