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[Sneezy12]

iiKiJ Pediatr Hematol Oncol. 2015 Aug;37(6):e368-71. doi: 10.1097/MPH.0000000000000337.
Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.
Suzuki R1, Kobayashi C, Sakai A, Fukushima H, Tagawa M, Satomi K, Nanmoku T, Sumazaki R, Fukushima T.
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Abstract
Imatinib mesylate has dramatically improved the outcome of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL) and is now included as first-line therapy. Uncommon adverse effects of this drug for pediatric use, however, are largely unknown. We report the first case of a 9-year-old child who developed severe acute hepatitis with grade 4 transaminases and bilirubin elevation during imatinib treatment for Ph ALL. Liver biopsy showed extensive lobular and pericentral necrosis of hepatocytes. Liver function recovered after discontinuing imatinib with a 4-week prednisolone. Extensive hepatic necrosis should be considered not only in adults but also in children under imatinib administration.
PMID: 25929609 [PubMed - in process]
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[Trey]

A second option is she may have contracted the hepatitis virus.

 

http://www.webmd.com...epatitis-basics

Edited by Trey, 05 August 2015 - 09:17 AM.