Posted 27 July 2015 - 07:15 PM
Buzzm - Some of my favorite workdays were spent at the Clairton and ET plants. Now I'm mostly working downtown - er - DAHNTAHN. I miss the free parking....
BTW - I'm skeptical about any link between CML and smoking....
Went dahntahn to see the Stillers play Worshington and wound up meetin' yunze gize who hadn't et yet so we had sammiches and Iren City near the pahrk.
Rilly? Get aht! Were they Primanni sammiches with fries n coleslaw n 'at?
Hey! I was dahntahn today. I stopped at Primanni's for a sammich with slaw
see, that's what I mean about the great things in southwestern PA; the Steelers, Iron City, Primannis, and the dialect ...
BTW, I never had a PA accent, or the dialect, but am always able to readily identify others from the great state of PA ...
I miss the local food there, and it's dinner time here ... wishfully thinking
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
Trey's CML Blog - Stopping - The Odds - Stop Studies - Discussion Forum Cessation Study
Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt