Posted 09 July 2015 - 03:25 PM
Yeah that's what I've been thinking over the last 24 hours....hoping for a good result the next PCR. If I have to go back to M, T, W, F or everyday as most folks do, it won't be a problem as I have always tolerated Gleevec well. I'm 35 years old and really just want to keep moving forward with life.
You should take Gleevec every day and get your PCR down like it was before. Only when you are PCRU for a period of time could you decide to try and reduce dose or stop like you were doing and see if it works.
This is important - you have lost major molecular remission (> 0.1% IS). That is a significant marker. Experiments of the type you are doing (every other day or less) is fine when you are below 0.1% - not much worry there. But you now have evidence of a rising PCR above MMR due to not taking enough drug. You run the risk of significant disease progression.
You mention you tolerate Gleevec well - that is wonderful - so take it. Every day. And you will not have to be concerned about CML (as much) and what day is what.
To quote Trey, "The current dosing schedule is not adequate". And you did have a dosing schedule in the beginning that worked well for you. Go back to it.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"