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Changed Oncologists and BCR/ABL help

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#1 hippychic


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Posted 06 July 2015 - 02:22 PM

Hi all,


In May, I had to change my insurance and my Docs didn't accept my new one. I had a lot of trouble getting a referral, changing over to the new insurance, and getting authorizations for everything. Because of all the changes and miscommunications, I ended up without my Gleevec for almost 6 weeks.  My last BCR/ABL was the first week of March and was 0.084 (IS) and testing was always sent to same lab..Qwest in Virginia.


Last week, I saw my new Onc for the second time, and this was the first time we did the Bcr/Abl. I just got the results back. They were sent out to the Mayo clinic Labs and I received the results today through the online medical records system. The first thing I looked for was, of course, the number. Well, no number..Instead I see the statement..".Negative. No BCR/ABL mRNA transcripts were detected." Yay!! However in reading a bit more on the report, I see this was a Qualitative test, so now I'm confused. do I need a Quantitative test? I know you all can relate..my life has revolved, for the last 22 months around this number.. Now I don't have one or need one? I really thought for sure it had gone up since I was without the Gleevec 400mg for so many weeks.


Should I call my Dr and ask for the Quantitative test? Can I ask to lower my Gleevec now? And what will the monitoring be like now there is no detection? I've been going for 3 month check ups since December.



#2 Antilogical


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Posted 06 July 2015 - 03:32 PM

If the Qualitative test is POSITIVE, then a Quantitative test is done to determine the BCR/ABL count.

If the Qualitative test is NEGATIVE, then a Quantitative test is not done, because... NEGATIVE!



Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.

Rx: 03/2012-Gleevec400.  Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).

Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.

#3 Lucas


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Posted 06 July 2015 - 04:42 PM

antilogical is right. it happened to me. the qualitative test is more sensitive than the quantitative. i had a positive qualitative but a "less than detection limit" quantitative (i had the bcr-abl, but they couldn't give me a number because it was too low). But you have to put in your mind 2 things: 1 - the sensitive of the labs can vary a lot, some can run 5 logs pcr and others just 4 logs; 2 - try to find when the sample was taken and when they ran the pcr. if it was more than 48 after the sample was taken, then the result could be lower than the "real" result. good luck and congratulations!

#4 gerry


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Posted 06 July 2015 - 08:34 PM

I originally had quantative results, then got a qualitative result of Positive, but below the reported limits, next test result was negative.


Feel free to get a bit excited. :)

#5 CML2012


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Posted 08 July 2015 - 09:45 PM

I posted "question about my pcr and new lab" a few weeks ago. Very similar situation.
Diagnosed CML December 2012
Gleevec 400 mg
PCR 53%, 41%, 1.69%, 5.63% (Mutation test negative) September 2013
Sprycel 100 mg
PCR 1.1%, 0.2%, 0.2%, 0.6%, .09%, .06%, PCRU June 2015, PCRU Sept 2015, PCRU Dec 2015, 0.042% Mar 2016, 0.122% April 2016, 0.19% June 2016, 0.176% July 2016, .052% Sept 2016, .031% Nov 2016
Diagnosed Basel Skin Cancer December 2012, October 2014 (All cancer removed)
Diagnosed Melanoma April 2015 (All cancer removed)

#6 Sneezy12


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Posted 09 July 2015 - 06:46 AM

Mayo Labs always indicate the date and time the specimen was received, and the time the test was run. Frank

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