What is a Sprycel "rash" exactly? What does it look like? Is it relieved with dose reduction? Prednisone? I have had an all over body rash for the last 5+ years since starting dasatinib. It is getting worse. My skin is also just breaking open at just a small touch. Whenever my kids touch me, my skin breaks open--seriously--and they are not coming at me with knives, just jagged little finger nails. My hem/onc does not want to touch side effects. And lately, I have seen doctors that tell me I need to go off Sprycel for certain meds to work. Like, I am all out of options for antibiotics that don't react with the drug and one that I can take and not get violently ill from. I have an hem/onc who won't approve lowering my dose. Does anyone here know of a CML expert in Chicago not from NU. I have already been there and found they know very little about CML. Very into SCTs as a cure-all. The hem/onc there told me at dx she wanted to give me one at 50. Her plan was that I stay on Gleevec, never swtich to 2nd generation drugs--despite my response, and get a SCT at 50 to cure me (not sure why she picked 50, maybe that is the end of the line for being young enough for a SCT to work well). The day she said this, I ran as far as I could (thanks to this board). I have been PCRU/MMR off and on on dasatinib for the last 2+ years. Hope I can make it to 50 without the need for a SCT like doc at NU predicted (or told me that was going to happen) so long ago. This is why I am scared to go to NU. Her words still haunt me. She is the embodyment of Satan. Maybe a CML expert would be willing to play with my dose to see if my rash improves (and lung issues--I am still sorting this out). Does anyone know if Dr. Talzpez supports dose reduction for side effects and very low counts?