and some more details here:
Posted 13 May 2015 - 06:42 PM
Posted 15 May 2015 - 02:15 PM
Thanks for the research. Good to see so much drug development is going on. When they talk about blast crises, are they meaning at initial diagnosis or can people develop blast crisis after starting TKIs? I would think with testing you'd see it coming on in the TKI resistant patient before it proceeded to blast crises.
Luckily most people dont go into blast crisis after starting TKI`s, but progression can occur even when on a TKI.
I dont know the percentage, but its low, and after achiving CCyR or better, the chance of progression is very small .
Even though they can treat it with a BMT, its a good thing they focus on developing drugs for BC CML.
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