Background... I had an early and deep response to 400mg Gleevec, but dropped back to 300mg due to significant side effects. I'm no longer undetected, but my PCRs have been stable at 4+ logs for over 2 years. My onc is considering a move to Tasigna to reduce the edema and unpleasant GI issues, but I am concerned about the increased cardiovascular risks.
Hmmmm... I started thinking about the best and worst of the 3 main TKIs. What if we could have the best of both worlds? Has anyone tried combining a half-dose of Gleevec & Tasigna? I have not been able to find any recent studies, but I'd sure be interested.
On 2nd thought, what if it resulted in the WORST of both worlds?