Inhibiting TNFa suppresses the immune system. That is what I mean when I say curcumin is a natural anti-inflammatory. Suppressing the immune system is not something you want to do during TKI cessation if success relies on the body's immune system to control the residual disease.
Here we go again ...
Curcumin is NOT a TNF blocker. TNF is vital for immune response (especially lymphatic response). But "over" expression of TNF can cause inflammation as well as accelerate myeloid cancers and other nasty autoimmune problems.
Curcumin is a down-regulator of TNF. Keeping genes running properly is what "food" is all about - especially plants. Natural down-regulators are vital for NORMAL cell function. Run-away cell growth almost always involves genes being turned on to "over express". Being able to "down regulate" is vitally important for the body's own systems to defeat cancer (through DNA repair, P53 gene expression & apoptosis). A true TNF inhibitor is likely to have significant side effects (including other cancers) if a patient is treated for long time this way. Perhap necessary in the short term to save a life, but perhaps trading big problems down the road.
Down-regulating the biochemical pathways that are necessary for CML to progress is a valuable area of research. Often the down regulation is fatal to a cancer and not to the normal cells. Plant phytochemicals, in general, (garlic, onions, Turmeric, Tomatoes, Potatoes, grapes, etc.) contain all sorts of chemicals that down-regulate our genes. And these plants have been around for millions of years (as long as mankind has been around eh?).
As I have said before - it's all about population control and which one dominates - the normal cell population or the cancerous one. Down regulation is an important way for our bodies to get control when systems get out of whack.
And that brings me to vitamin D ... (I'll stop here Trey ... topic for another day).
p.s. Anyone take Aspirin? Aspirin is a potent TNF down-regulator. And more potent than Curcumin (because of its easy bioavailability) (http://www.researchg...sue_macrophages). There is data for Aspirin effects on solid tumors, but not Leukemia.
And then there's garlic - we all like to eat garlic with our pasta sauce - yes?
Garlic is a potent TNF down regulator. And garlic has been shown to drive Leukemia cells into apoptosis.
Neither Aspirin or Garlic (and the other plant stuffs) hurt our immune system. If anything, they help our immune system run right. And the same goes for Curcumin
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"