Posted 09 September 2015 - 08:26 AM
I take 300 mg. Imatinib. I have never taken the Brand name, it has always been the genetic. It's probably all the same. My Insurance only pays for genetic.Your opinion and comments are very much appreciated.
Congratulations on your continued progress acl. Just curious about the cost of the generic Imatinib you take and who the manufacturer is. Imatinib is scheduled to go generic in the U.S. on 02/01/2016, produced by Sun Pharma, but the pricing of the generic is unknown at this time.
Novartis manages to push back competition to its leukemia drug in the U.S. http://on.wsj.com/1lCYBdg
For the benefit of yourself and others please add your CML history into your Signature
02/2010 Gleevec 400mg
2011 Two weakly positives, PCRU, weakly positive
2012 PCRU, PCRU, PCRU, PCRU
2013 PCRU, PCRU, PCRU, weakly positive
2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)
2015 300, 250, 200, 150
2016 100, 50/100, 100, 10/17 TFR
2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000
2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17
At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.
In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.
longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation. GFR and creatinine vastly improved after stopping Gleevec.
Cumulative Gleevec dosage estimated at 830 grams
Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.
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