Hi. I was on Gleevec for 9 years. Towards the end of my Gleevec usage I actually ended up in the ER because my muscle cramping got so bad I literally ended up on the floor on my knees. I would get cramps in my torso ( on the sides), my fingers, my arms, feet, legs, neck etc. It was dangerous to drive if I would get one in my foot or leg. Every time I went for a procedure, lying down on the exam table would trigger them in my torso, the staff would look at me like a was an alien, I couldn't breath or talk, the pain was excruciating and there was nothing I could do except wait it out. The time I ended up at the ER they said my electrolytes and labs were "normal." No explanation. So they gave me muscle relaxants, which is fine, unless you'd like to be functional for the day. I found taking magnesium helped some, I actually took a store brand calcium, magnesium, and zinc combo supplement. After 9 years of the misery of Gleevec side effects, I finally bit the bullet and switched to Sprycel. Started on a 70mg and the side effects were horrible. (but due to memory loss from tki's , I can't tell you exactly what they were, but they were horrible). Doc knocked me down to 20mg. I had been in complete molecular remission for 8 years on Gleevec. My numbers jumped up at little after the switch but dr held out with me on 20mg and they eventually went back to undetectable. Maintaining undetectable now. Still have debilitating joint pain, and other issues but the cramps are completely gone, as is the eye swelling, and constant diarrhea. Its still not a picnic, but so much better than it was. I thank God for Gleevec and CMR, but I am so grateful Sprycel was discovered since then and is much kinder to me.