Hi, dlberger. . .
I had pretty awful foot and hand cramps while on Gleevec. It was usually my right foot and left hand. The fingers and toes would totally freeze up in crossed positions. It was really odd because I could feel it coming on and then could actually see my fingers moving on their own. They would cross over one another and then freeze into position. I would have to physically pull them apart with my other hand. Extremely painful.
They would, of course, do this at inopportune times. The worst was riding my trail motorcycle up a rocky section of trail. Clutch hand froze up when I needed to shift into lower gear. Not good.
I switched to Sprycel due to suboptimal response, and since my switch haven't had a single hand or foot cramp.
Good luck. If your cramps are anything like mine, they are painful and momentarily debilitating. I'm glad to be rid of them. Of course, Sprycel has its own side effects.