I am on my third TKI (Tasigna, Sprycel and now ponatinib). I was diagnosed with CML on 4/3/14. My onc had me on ponatinib 15 mg beginning in January and switched me to 30 mg in March when my PCR went up slightly from 9% ( the lowest since diagnosis) to 12.26%. Most recent PCR is 10.8%. Since the switch to 30 mg, I have had 6 platelet transfusions (transfused at 15,000 and under) and 2 blood transfusions (transfused at 8,000 and under) in addition to 2x weekly neupogen injections (shots when white count is 2,500 and under). The ponatinib is clearly raking havoc with my blood counts but my onc feels that lowering the BCR/ABL is the most important part of my treatment. He will leave me at the same ponatinib level and repeat the PCR at the beginning of May. This is so frustrating and I am at City of Hope 2x week for blood counts. OUCH!! Onc says that if I don't respond favorably he will consider switching me to Bosutinib which means I am running out of options. Onc told me on Friday not to be discouraged that some people just take longer than others to respond. Obviously, this is easier said that done especially since I have never missed a dose and I have no mutations. Anyone else out there have such low blood counts and then finally responded to the treatment??? I know that the majority of people in this forum are undetectable but I am wondering about the rest of us who are not.