I feel there is a little bit of slowdown in finding new drugs or combination therapy for finding cure or destroying Leukemic stem cells especially in 2013, 2014 and 2015. I see even number of research papers have slowed down in this area and not many trials using new drugs, therapies or approaches.
I am not hearing any new information in this area or renewed interest on trials other than STIM trials that may not be suitable for everyone. Most people see their PCR bounce and lose response when they stop TKI's.
The only thing that can slow this down is to hit Leukemic stem cells(killing LSCs) and handling T315i mutation which is proving to be deadly but I see no new drugs other than ponatinib which introduced some serious side effects for many and even serious CVD events.
May be the big pharma lost interest here.... No incentive since they want people lifetime on TKI's, that is the core revenue model... right?
Any other thoughts or information???