Which cholesterol medications are ok with Sprycel? I was taking Simvastatin but was just told I have to stop due to drug interaction. Has anyone switched off Simvastatin to something else?
Lisa L
Cholesterol med interactions on Sprycel
Started by
Lisa Lisa
, Mar 17 2015 09:19 AM
Sprycel Cml Cholesterol medication Sprycel cholesterol
11 replies to this topic
#1
Lisa Lisa
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Posted 17 March 2015 - 09:19 AM
Dx 2/2015 BCR-ABL1 (p210) 85.2% (IS) 3/15
22% 5/15 0.13% 6/15 PCRU attained 9/15
Initial dose Sprycel 100 mg 3/15 Lowered 80 mg 5/15 Lowered 50 mg 1/16
Note: dose lowered bc of side effects - not bc onc wanted to reduce dosage
Sprycel: Currently 50 mg per day - taken 10 pm
#2
Trey
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Posted 17 March 2015 - 12:19 PM
You can check for interactions:
http://www.webmd.com...action-checker/
For Sprycel and Simvastatin, the problem is the Simvastatin effects are enhanced, like taking extra dosage.
Also, you may find that Sprycel lowers your cholesterol by itself. Others here have experienced this. You might consider asking your doc if you can try just taking the Sprycel for a while.
#3
Gail's
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Posted 17 March 2015 - 02:23 PM
Just stopped simvistatin myself. Onc pharmacist told me gleevec makes it 2-3 times more effective. Can cause muscle weakness, pain an neurological symptoms.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
#4
Antilogical
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Posted 17 March 2015 - 03:39 PM
I developed rhabdomyolysis due to interactions between Zocor (simvastatin) and a blood pressure drug. That landed me in the hospital for 5 days while they flushed it out of my system. Now I take Crestor (rosuvastatin Ca) on weekdays, and skip it on weekends to give my bad self a break. I've been following that schedule for 10 years without any more problems, even on the Gleevec..
Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.
Rx: 03/2012-Gleevec400. Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).
Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.
#5
Billie Murawski
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Posted 18 March 2015 - 01:50 AM
I stopped taking Lipitor 40 mg about a week ago because I thought it might be causing my rls now I'm not to sure if that's my problem or not I've been on L for about 10 years, my rls is better but I still have it. I haven't talked to doc about it yet. Years ago I asked him about simvastatin and he said no.
AL I just remembered something I take .01 mg of clonidine 2x a day for my bp and last summer I was put on bystolic 5 mg a day also for bp, I wonder if those meds are causing my rls. I take Plavix and a full strength aspirin a day also.I've been on them for about 10 years also. I never had bp problems before I went on Sprycel my bp use to always run low.
Any feedback would be appreciated! Billie
#6
Lisa Lisa
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Posted 18 March 2015 - 01:57 AM
Billie did you start on Sprycel or Gleevec?
Dx 2/2015 BCR-ABL1 (p210) 85.2% (IS) 3/15
22% 5/15 0.13% 6/15 PCRU attained 9/15
Initial dose Sprycel 100 mg 3/15 Lowered 80 mg 5/15 Lowered 50 mg 1/16
Note: dose lowered bc of side effects - not bc onc wanted to reduce dosage
Sprycel: Currently 50 mg per day - taken 10 pm
#7
Billie Murawski
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Posted 18 March 2015 - 02:24 AM
Lisa, I started on Gleevac and I'm much happier on Sprycel even though I had to go through what you are going through now!
#8
hannibellemo
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Posted 18 March 2015 - 06:48 AM
Lisa,
I'm on 50mg of Sprycel and I take 10mg. atorvastatin (generic Lipitor) every night before bed. Have for 2+ years.
Good luck!
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
#9
chriskuo
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Posted 18 March 2015 - 10:45 PM
Sprycel 50 / atorvastatin 10 worked for me. Only problem was the effusions caused by Sprycel.
#10
Billie Murawski
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Posted 18 March 2015 - 10:56 PM
Maybe I can get my lipitor dose lowered.
#11
Lisa Lisa
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Posted 02 November 2015 - 11:24 PM
Lisa,
I'm on 50mg of Sprycel and I take 10mg. atorvastatin (generic Lipitor) every night before bed. Have for 2+ years.
Good luck!
Hannibellemo,
Are you still taking the generic lipitor? And do you take them many hours apart?
Dx 2/2015 BCR-ABL1 (p210) 85.2% (IS) 3/15
22% 5/15 0.13% 6/15 PCRU attained 9/15
Initial dose Sprycel 100 mg 3/15 Lowered 80 mg 5/15 Lowered 50 mg 1/16
Note: dose lowered bc of side effects - not bc onc wanted to reduce dosage
Sprycel: Currently 50 mg per day - taken 10 pm
#12
hannibellemo
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Posted 25 November 2015 - 09:03 AM
Lisa,
Just saw this post. Yes, I take Sprycel around 8 a.m. and atorvastatin about 12 hours later.
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
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