I am new to this forum. I was diagnosed with CML in April 2014 at City of Hope; Sokal high risk, englarged spleen, WBC of almost 500,000 and platelets over 1,000,000. I was put on Tasigna, then Sprycel and now Iclusig. My PCR at diagnosis was 146% and even though Tasigna and Sprycel brought my BCR-ABL down to as low as 30% it did not go any lower. Tasigna failed and I experienced also swelling of feet, hair loss, and increased liver toxocity. My dr. changed me to ponatinib because the PCR while on Sprycel indicated 45%. I am tolerating the ponatinib however dr. has increased the dosage from 15mg to 30mg because BCR-ABL went up from 9.01 % to 12.26%. Ponatinib is causing my blood counts to be very low; 1.7 WBC; platelets to 12,000, and Hemoglobin 8.1. I have received weekly injections of neupogen and last week both a platelet and a blood transfusion. I am frustrated and coming up on the 1 year of diagnosis and certainly worried about what my future holds. Anyone else experienced the same?? Any advice???