I noticed that a lot of people here are quite knowledgeable. So here is a simple question that I can't seem to answer on the Internet, and I always forget to ask my oncologist.
Why is the philadelphia chromosome called "philadelphia" to begin with?
8 replies to this topic
#1
Dom
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Posted 08 March 2015 - 08:45 PM
Diagnosed in February 2014. Started Imatinib 400 in April.
2014: 3.18 0.91
2015: 0.22 0.16 0.04 0.55
2016: 0.71 0.66
(Started Imatinib 600 in April 2016)
2016: 0.42 0.13 0.45
2017: 0.17 0.06 0.10 0.06 0.34
#2
Dom
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Posted 08 March 2015 - 09:26 PM
Okay, I just went through some of the material that Trey posted. It was discovered in Philadelphia. Question answered. Does anyone know where in Philadelphia? Fox chase, temple, penn?
Diagnosed in February 2014. Started Imatinib 400 in April.
2014: 3.18 0.91
2015: 0.22 0.16 0.04 0.55
2016: 0.71 0.66
(Started Imatinib 600 in April 2016)
2016: 0.42 0.13 0.45
2017: 0.17 0.06 0.10 0.06 0.34
#3
pammartin
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Posted 08 March 2015 - 10:53 PM
1962 ish by Peter Nowell at the University of PA school of medicine I think. It is in Trey's info I think.
#4
gerry
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Posted 09 March 2015 - 01:25 AM
Posted: November 05, 1993
David A. Hungerford, 66, a researcher at the Institute for Cancer Research at Fox Chase Cancer Center who co-discovered the first evidence that abnormal chromosomes can cause cancer, died Wednesday at his home in Jenkintown.
In 1959, in collaboration with Dr. Peter C. Nowell at the University of Pennsylvania, Dr. Hungerford found that cells from patients with a certain type of leukemia had a shortened chromosome 22.
http://articles.phil...avid-hungerford
#5
Trey
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Posted 09 March 2015 - 09:50 AM
Nowell and Hungerford discovered that the Philadelphia Chromosome existed as a mutated chromosome, but then Janet Rowley discovered it was the result of a reciprocal translocation between chromosomes 9 and 22. Both of these discoveries together formed the basis of the advances in research which led to today's TKI drugs about 2 decades afterward.
Here is the best history of CML and the Philadelphia Chromosome by Dr Brian Drucker:
http://www.bloodjour...so-checked=true
http://www.cmleukemi...t-d-rowley.html
http://www.ncbi.nlm....les/PMC1934591/
Edited by Trey, 09 March 2015 - 09:52 AM.
#6
Marnie
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Posted 09 March 2015 - 05:11 PM
Trey. . how about reposting the information about the woman whose generous donation of her leukemic cells to science after her death resulted in the development of Gleevec. That is great reading for new members to the club. I don't have the link for it, but I'm guessing you know where it can be found.
#7
pammartin
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Posted 09 March 2015 - 08:28 PM
I would enjoy reading that story, Marnie. Thanks for bringing it up. I will haunt thread to see if link appears.
#8
Trey
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#9
Gail's
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Posted 10 March 2015 - 09:59 PM
Amazing story.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088
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