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Skin rash and Gleevec

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#1 alc999


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Posted 19 February 2015 - 09:39 AM

I've been on Gleevec 400mg for exactly 2 weeks now, and today I woke up with a rash over my torso, legs, arms, and some of my face. It's itchy red bumps and blotches. Has anyone else experienced this and has it gone away with time?
Thanks so much!

01/15: Diagnosed, 195% PCR, 100% FiSH, Began Gleevec 400 mg per day

04/15: 58.1% PCR

08/15: 1.6% PCR, 0% FiSH

11/15: 0.6% PCR

02/16: 0.4% PCR

05/16: 0.1% PCR

09/16: 0.3% PCR, Began Gleevec 600 mg per day

12/16: 0.1% PCR

03/17: 0.2% PCR, Began Tasigna 600 mg per day

07/17: 0.08% PCR

#2 August1


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Posted 19 February 2015 - 09:56 AM

Hi, I think rashes are pretty common as a side effect. I am on Sprycel and have all sorts of minor skin issues. Others here have mentioned rashes as well. They can go away with time and in some cases over-the-counter remedies can help or a dermatologist can prescribe something as well. 


Take care,

#3 Gail's


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Posted 19 February 2015 - 03:10 PM

Alc999, I think you should check in with your dr due to the suddenness of onset and how widespread the rash is. Like Bill S said, could be a side effect but could also be allergic reaction to med, in which case it would be advisable to stop the med. one test for allergic reaction is to take some Benadryl to see if it subsides but I really think you need eyes on by your dr.
Diagnosed 1/15/15
FISH 92%
BMB 9:22 translocation
1/19/15 began 400 mg gleevec
1/22/15 bcr 37.2 IS
2/6/15 bcr 12.5 IS
3/26/15 bcr 10.3 IS
6/29/15 bcr 7.5 IS
9/24/15 bcr 0.8 IS
1/4/16 bcr 0.3 IS
Started 100 mg dasatinib, mutation analysis negative
4/20/16 bcr 0.03 IS
8/8/16 bcr 0.007 IS
12/6/16 bcr 0.002 IS
Lowered dasatinib to 70 mg
4/10/17 bcr 0.001 IS
Lowered dasatinib to 50 mg
7/5/17 bcr 0.004 IS
8/10/17 bcr 0.001. Stopped TKI in prep for September surgery.
9/10/17 bcr 0.006
10/10/17 bcr 0.088

#4 jmoorhou


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Posted 19 February 2015 - 04:46 PM

I too would actually go the the ER immediately.  In the info I got from my Onc Gleevec has caused Stevens-Johnson, which you don't want to get.


I had rashes with 400 mg Gleevec I went to ER got a shot of prednisone, and cut down to 100 mg Gleevec, and built up to 400 again with no rashes.

Diagnosed 3/2014 WBC 28 Non detectable within 3 monthsGleevec 400 mg 5/2014 one hour after dinner really improves nausea300 mg 12/15/2016200 mg and 300 mg Gleevec 2/25/2017 (after 3 years on Gleevec) For last four months taking 300 mg per day. Last CMC showed liver enzymes elevated, went to a good Naturopath and he recommended 4 Tumeric, 10,000 mg Vitamen D, and 3 milk thistle (silymarin) daily. Also use One<p>Day Detox Dandeloin tea, and Nettle Tea and a slice of ginger every day...in two months liver tests were below normal.Janis

#5 gerry


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Posted 19 February 2015 - 07:54 PM

I had the rash on the back of my legs, I took an antihistamine daily and used a topical antiseptic cream. It took a week or two for the rash to disappear and it tried to make a reappearance when I got a virus a few months later.

See your doc just to be sure.

#6 Antilogical


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Posted 19 February 2015 - 08:27 PM

I am on Gleevec and recently had a pretty significant allergic response.  When the doc saw my blood tests, he told me he thought I might be allergic to Gleevec, but since I was tolerating it, to start taking an antihistamine.  Done.

Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.

Rx: 03/2012-Gleevec400.  Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).

Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.

#7 Trey


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Posted 20 February 2015 - 01:06 PM

It is fairly common, but yours is a bit more widespread than usual.  There are several types of skin reactions caused by Gleevec.  Most are fixed by a temporary drug holiday, and most times the reaction does not recur, at least not as significantly.  Often a steroid cream will be prescribed.


Unless this reaction started with flu-like symptoms it is probably not Stevens-Johnson which is a very severe skin issue, and probably the only one which is an emergency situation.  Otherwise check with your Onc who should tell you to stop the Gleevec for at least a week.

Edited by Trey, 20 February 2015 - 01:07 PM.

#8 clford


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Posted 20 February 2015 - 01:56 PM

Hi Alissa,

I  encountered the same rash issues last year. I went to a dermatologist. She had given me creams with steroids to apply to the rash areas. What a relief this was. I was sorry i did not go sooner.  I also had rash on my torso, thighs, eyes, face. The creams took the rashes away. I still have outbreaks and i use the creams when this happens. The dermatologist was able to give me samples, so it was not an out of pocket expense. 


#9 Melanie


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Posted 20 February 2015 - 03:37 PM

Hi Alissa. I had an allergic reaction to Gleevec. Rash and hives all over my torso. My onc took me off Gleevec and gave prednisone to clear it up. Started again and within a day, broke out again with more severe hives. Went on like this for a while with drug breaks, lower dosages, more prednisone, steroid creams, etc. In the end it was decided, I just couldn't tolerate Gleevec. Definitely check with your Doctor.
Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

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