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Q.PCR Response to treatment (CML)


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#1 acl

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Posted 03 February 2015 - 09:08 PM

Hi Trey and Everyone, I had Q.pcr  test (peripheral blood) done Dec. 2, 2014, and I would like to know your opinion on the measurement.

 

Log Reduction 2.2  IS-NCN 0.72

 

I am very happy that my blood results have normalized, the Red Cell is a little high

15.4, normal range is 11.5-14.5. I am moving like a turtle. My hematologist ordered another Q.PCR test today, he is ordering it every two months, with a blood test each month. I was diagnosed March 2014, and I take 300 mg. Imatinib (generic)

 

Thank you

Adela


Diagnosed March 2014

Imatinib 400 mg. Summer 2014, Imatinib 300 mg.

 

% BCR-ABL

IS-NCN

 

06/01/16     0.18%

24/02/16     0.11%

23/03/16     0.13%

12/05/16     0.07%

13/07/16     0.17%

12/09/16     0.12%

21/19/16     0.15%

23/11/16     0.09%

20/12/16     0.11%

19/01/17     0.07%

21/02/17     0.07%

20/03/17     0.06%

20/04/17     0.06%

20/05/17     0.07%

20/06/17     0.06%

23/08/17     0.08%

22/12/17     0.04%

 

 

 

 


#2 Trey

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Posted 03 February 2015 - 09:14 PM

It is between CCyR and MMR.  If a person could remain stable in this area that would be fine.  But we all want to be MMR or better.  But stable is good.

 

The high RBC is a bit unusual.  Maybe you should post your entire CBC.



#3 acl

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Posted 03 February 2015 - 10:02 PM

Hi Trey, Thank you for your opinion.

TEST; CBC AND DIFF. collected Date & Time: 02/03/15 12:31

Result name:                                   Results:                   Reference Range:

LEUKOCYTE COUNT                     4.3                           4.0-11.0

ERYTHROCYTE COUNT                3.84                         3.80-5.20

HEMOGLOBIN                                124                           115-165

HEMATOCRIT                                 0.363                        0.360-0.460

MEAN CELL VOLUME                     94                             78-100

MEAN CELL                                     32.2                           27.0-0.34.0

HEMOGLOBIN

MEAN CELL                                     341                            320-370

HEMOGLOBIN

CONCENTRATION

RED CELL                                        15,4H                         11.5-14.5

DISTRIBUTION WIDTH

PLATELET COUNT                           164                            150-400

MEAN PLATELET                              7.7                             3.5-11.0

VOLUME                                           

NEUTROPHILS                                  0.47

LYMPHOCYTES                                 0.42

MONOCYTES                                     0.08

EOSINOPHILS                                    0.02

BASOPHILS                                         0.01

NEUTROPHILS#                                  2.0                            1.5-8.0

LYMPHOCYTES#                                 1.8                            1.0-4.8

MONOCYTES                                       0.3                            0.0-1.5

EOSINOPHILS#                                   0.1                             0.00-0.50

basophils#                                            0.0                             0.0-0.3

LACTATE DEHYDROGENASE (cell turnover) 688H            313-618

 

Your opinion is appreciated.

Adela


Diagnosed March 2014

Imatinib 400 mg. Summer 2014, Imatinib 300 mg.

 

% BCR-ABL

IS-NCN

 

06/01/16     0.18%

24/02/16     0.11%

23/03/16     0.13%

12/05/16     0.07%

13/07/16     0.17%

12/09/16     0.12%

21/19/16     0.15%

23/11/16     0.09%

20/12/16     0.11%

19/01/17     0.07%

21/02/17     0.07%

20/03/17     0.06%

20/04/17     0.06%

20/05/17     0.07%

20/06/17     0.06%

23/08/17     0.08%

22/12/17     0.04%

 

 

 

 


#4 Trey

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Posted 03 February 2015 - 10:23 PM

Oh, so you meant RDW is 15.4    No big deal. 



#5 acl

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Posted 03 February 2015 - 10:40 PM

Thank you Trey!

 

Adela


Diagnosed March 2014

Imatinib 400 mg. Summer 2014, Imatinib 300 mg.

 

% BCR-ABL

IS-NCN

 

06/01/16     0.18%

24/02/16     0.11%

23/03/16     0.13%

12/05/16     0.07%

13/07/16     0.17%

12/09/16     0.12%

21/19/16     0.15%

23/11/16     0.09%

20/12/16     0.11%

19/01/17     0.07%

21/02/17     0.07%

20/03/17     0.06%

20/04/17     0.06%

20/05/17     0.07%

20/06/17     0.06%

23/08/17     0.08%

22/12/17     0.04%

 

 

 

 


#6 hannibellemo

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Posted 05 February 2015 - 11:21 AM

This threw me too, when I first saw it on a report, Adela. Erythrocyte is the same as RBC.

Pat

 

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>





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