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question about TKI's

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#1 dede5


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Posted 22 January 2015 - 12:40 PM

Will TKI's affect your organs like regular chemotherapy does? I was in pretty bad shape by the time I started treatment for my CML, so didn't have the presence of mind to question anything he said or did. I just did what my doctor told me to do and have continued to do it blindly because it keeps me alive, so I figured it was the right thing. Now, I'm reading that people have their doses adjusted at different times. I can live with the side effects I have, but have started to wonder what it's doing to my internal organs over a period of time. I take Sprycel 100mg.

Dx: 01 March 2011

Sprycel 100 mg per day since dx 

MMR: July 2013

numerous side effects 

Thankful for the gift of each new day, and try to live it to the fullest  :D

#2 hannibellemo


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Posted 22 January 2015 - 02:32 PM

While traditional chemotherapy agents aim to destroy rapidly dividing cells, our TKIs interfere with the development of cancer at the molecular level. They're sometimes called molecular-targeted treatments or just targeted therapy.

Targeted therapies are more selective than traditional cancer therapies and spare more healthy cells. 

Because these drugs are so new, I personally feel that once the cancer load is reduced to a safe level and remains there for a period of time, then thought should be given to reducing the dosage to find a maintenance level that's right for each person.

I was taking Sprycel 100mg. but was reduced to 50mg after a PE. That has, so far, kept me in MMR. 

I'm going to explore raising it to 70mg. for a time to see if that will get me to PCRU. Maybe that just isn't in the cards for me, in which case I would probably ask for it to be reduced to 50mg. again.

I think there is wiggle room with these drugs for some, if not, most of us. My opinion only.



"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

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