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Tasigna - how long will it take my body to adjust?


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#1 jrb666

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Posted 30 November 2014 - 09:10 AM

Recently diagnosed and this is day 4 on Tasigna. I am having leg pain like I've never felt before, from my hips down to my knees. It seems to feel better if I am moving around, but I am exhausted and can't seem to find a comfortable position to rest in.

How long will it take my body to adjust? This is very discouraging. I am taking ibuprofen, but it's not helping much.

Why the leg/hip pain? I know these are the largest bones in the body where a lot of the marrow is. Is this just the tki doing its job?

#2 Trey

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Posted 30 November 2014 - 10:22 AM

These are side effects of the drug and does not indicate much except that the drug is being absorbed from the alimentary canal, but during the first couple weeks there is enormous cell turnover as leukemic cells die in very large numbers, which can cause discomfort.  Stay well hydrated during this period to flush out the resulting urea.  

 

The intense leg pain will likely last a month or two, and after that it should decrease or maybe go away.  Over time most side effects go away as the body adjusts, but most of us still end up with a couple side effects over the longer term, even if at reduced levels. 



#3 garfonzo

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Posted 30 November 2014 - 06:46 PM

Ditto what Trey says. The first few months are the adjustment time but the side effects do get better and as the leukemic burden in your body flushes out you will feel better quickly.
1/22/2013 initial dx WBC 550k
1/28/2013 begin Tasigna 600

pcr test %IS Drug Dose
7/24/13 2.889 Tasigna 600
10/23/13 2.442 Tasigna 600
1/24/14 2.497 Tasigna 600
3/5/14 2.158 Tasigna 600
6/4/14 1.319 Tasigna 800
9/3/14 0.982 Tasigna 800
12/8/14 0.845 Tasigna 800
3/16/15 1.984 Tasigna 800
4/27/15 0.802 Sprycel 100 PM
6/22/15 0.277 Sprycel 100
8/24/15 0.466 Sprycel 100 AM
9/14/15 0.365 Sprycel 100 PM
11/9/15 0.307 Sprycel 100
1/6/16 0.1 Sprycel 100 - MMR mayo clinic
4/4/16 0.1 Sprycel 100 - MMR
5/9/16 0.1 Sprycel 100 - MMR
6/6/16 0.06 Sprycel 40 - MMR
7/6/16 0.1 Sprycel 40 - MMR
9/12/16 0.09 Sprycel 40 - MMR
11/15/16 0.1 Sprycel 40 - MMR
2/14/17 0.07 Sprycel 40 - MMR
5/16/17 0.06 Sprycel 40 - MMR
9/11/17 0.05 Sprycel 40 - MMR
1/15/18 0.05 Sprycel 40 - MMR




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