I finally got some new numbers. I'm kinda bummed cause I can't figure out how to compare them to where I was. They were done at different hospitals and labs. I know I started out with WBC of 256.2 and now my WBC is 6.94. The only actual numbers I can find on my BMB done when first diagnosed says myeloid:erythroid ratio is greater than 10:1 and the blood clot contains foci of marrow that are nearly 100% cellular consisting mostly of myeloid cells at all stages of maturation. I'm really not sure what that actually means, but I dodn't think it sounds very good. I don't believe that first onc ever gave me a copy of my BCR-ABL test results. My new test says Calculation is 3.2 and IS Calibrator Calculation is 0.70. I know the WBC is good. I'm thinking it's the IS calculation is what we're all trying to get down to 0.00. Is that right? And the U in PCRU means undetectable? I guess my biggest question right now is this good for being on 100mg Sprycel for 8 months?
Are these numbers good?
Posted 12 November 2014 - 05:17 PM
A .7% IS PCR at 8 months is ahead of schedule, so that is good. Below 1% IS is roughly Complete Cytogenetic Response (CCyR) which is the goal for 12 - 18 months. That is a zero BMB or FISH. One comment is that the difference between 3.2% and the adjusted .7% is larger than I usually see, so there is some room for error in there.
The PCRU is zero PCR, but the main goal is below .1% PCR IS. That is Major Molecular Response.
The items you quoted about the BMB language is standard at diagnosis. I assume your leukemic cell count was 100% which is what most of us were at diagnosis. BMB language should say something like "X out of 20 cells".
You can read more about CML testing here:
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users