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ASH Conference 2015


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#1 scuba

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Posted 07 November 2014 - 04:04 PM

The upcoming 2014 ASH Conference Abstracts are now available:

 

https://ash.confex.c...gram/start.html

 

One paper that caught my attention:

https://ash.confex.c...Paper72972.html

 

Last sentence, "This strategy has the potential to eradicate BC CML cells and CML stem/progenitor cells, neither of which are effectively targeted by TKIs alone."

BC = Blast Crisis.


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#2 Jerry.s

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Posted 07 November 2014 - 06:17 PM

I wonder what this means in English?

#3 scuba

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Posted 08 November 2014 - 09:21 AM

I wonder what this means in English?

 

ABT-199 is a new compound developed by Abbvie Labs that is now in clinical trials for Lymphoma and related cancers. They have found in early results that ABT-199 is effective at eradicating CML stem cells when used in conjunction with TKI's (Sprycel, Gleevec, etc.). The results are reported using mice. Human trials are next. This is a promising development.

 

Compounds are now being developed which can go after quiescent (sleeping) Leukemic stem cells. Our current TKI treatments are not effective at killing Leukemic stem cells by themselves which is why we relapse when stopping treatment. Combination therapy where both populations of cells are targeted (stem cell + daughter cells) is a promising approach.


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#4 JPD

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Posted 08 November 2014 - 10:27 AM

This is good news indeed.  Praise be (whoever or whatever or nothing at all)!


January 15: .53%

April 15:       .78%

July 15:      1.1% - upped dosage to 400mg after this test

Oct 15:       .85%

December 15:  .28%

March 16: .29%

July 16: .34%

October 16: .11%

January 17: .081%

April 17: .055%

July 17: .135%

Oct 17: .008%


#5 rcase13

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Posted 08 November 2014 - 02:29 PM

Well it is about time. I was diagnosed 6 weeks ago. That is more than enough time for them to cure cancer...

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg

 

Cancer Sucks!


#6 Jerry.s

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Posted 08 November 2014 - 03:04 PM

Cool thanks for dumbafying it for me , I was diagnosed 6 weeks ago as well and a cure would be beyond cool

#7 Buzzm1

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Posted 08 November 2014 - 03:12 PM

It's in the news: chronic myeloid leukemia


For the benefit of yourself and others please add your CML history into your Signature

 

02/2010 Gleevec 400mg

2011 Two weakly positives, PCRU, weakly positive

2012 PCRU, PCRU, PCRU, PCRU

2013 PCRU, PCRU, PCRU, weakly positive

2014 PCRU, PCRU, PCRU, PCRU (12/07 began dose reduction w/each continuing PCRU)

2015 300, 250, 200, 150

2016 100, 50/100, 100, 10/17 TFR

2017 01/17 TFR, 04/18 TFR, 07/18 TFR 0.0012, 08/29 TFR 0.001, 10/17 TFR 0.000

2018 01/16 TFR 0.0004 ... next quarterly PCR 04/17

 

At the earliest opportunity, and whenever possible, lower your TKI dosage; TKIs are toxic drugs and the less we take longterm the better off we are going to be ... this is especially true for older adults.  

 

In hindsight I should have started my dosage reduction two years earlier; it might have helped minimize some of the longterm cumulative toxic effects of TKIs that I am beset with.  

 

longterm side-effects Peripheral Artery Disease - legs (it's a bitch); continuing shoulder problems, right elbow inflammation.   GFR and creatinine vastly improved after stopping Gleevec.

 

Cumulative Gleevec dosage estimated at 830 grams

 

Taking Gleevec 400mg an hour after my largest meal of the day helped eliminate the nausea that Gleevec is notorious for.  

 

Trey's CML BlogStopping - The OddsStop Studies - Discussion Forum Cessation Study

Big PhRMA - Medicare Status - Social Security Status - Deficit/Debt


#8 TeddyB

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Posted 09 November 2014 - 10:07 AM

ABT-199 looks promising, how long until human CML trials?

 

 

My hangover suddenly got a lot better after reading this :)



#9 Lucas

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Posted 09 November 2014 - 10:46 AM

it looks very, very promising! there are some strategies like that. there's one that uses a drug for osteoporosis with TKI. 



#10 LivingWellWithCML

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Posted 10 November 2014 - 10:38 AM

Yes, very promising!  As often comes with these new developments, it discusses the potential for resistant and advanced-phase CML (blast crisis), which could be huge for these cases where one's life is at risk and the remaining options are limited.  This has the potential to be responsive, and even curative for those cases, which would be amazing.

 

What about implementing these combo-therapy approaches for chronic phase CML patients who are *already* responding well to treatment, so we can pursue treatment-free remission (TFR)?

 

Also, here's an article about 7 new compounds that are potentially more potent (and cheaper to manufacture) than the current TKIs:

 

http://timesofindia....ow/45084815.cms


Dan - Atlanta, GA

CML CP Diagnosed March 2011

Gleevec 400mg


#11 sunshineC

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Posted 10 November 2014 - 01:30 PM

Anyone else surprised by reading from the link Buzzm1 just posted.  Although it has several hopeful theories, I was a little taken aback by "Patients with chronic-phase disease can now expect a 10-year survival of more than 80%, and may potentially be cured with continued TKI therapy."  Granted, I obviously am a 'glass half empty' thinker, and maybe I am not understanding this at all, but I was under the belief that with TKI therapy that worked, we would be able to live our 'normal' lives out; never heard of a 10-year survival rate. ???  Can someone help me understand this better maybe?  Don't get me wrong, I am very grateful for the strides made and realize I am very lucky to be alive - for whatever time I may have.



#12 JPD

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Posted 10 November 2014 - 02:18 PM

A few things to remember - the 10 year survival rate means that 80% of all people with CML will be alive in 10 years.  Thats ALL that means.  It doesnt mean that you have a 20% chance of dying from CML, it doesnt mean that the TKI drugs only work for 80% of the people.  It just means that of the people in the study that had CML, 8/10 were alive ten years after the start of the study.

 

If someone dies of a shark bite at the age of 99, but also has CML - they will be part of that 20%.

 

As Trey points out often - I think if we achieve a good enough response and take our meds like we should, about 95% of us wont die from the CML.


January 15: .53%

April 15:       .78%

July 15:      1.1% - upped dosage to 400mg after this test

Oct 15:       .85%

December 15:  .28%

March 16: .29%

July 16: .34%

October 16: .11%

January 17: .081%

April 17: .055%

July 17: .135%

Oct 17: .008%


#13 sunshineC

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Posted 10 November 2014 - 05:12 PM

Thanks JPD for making that clear for me.  I knew I wasn't looking at that the right way.






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