2 replies to this topic

[Lucas]

hi everybody (hi trey). I was reading an old topic and trey talked about  "certain genetic advantages" that leukemic cells can have. what are these advantages? kinase mutations? chromossome mutations? anything else? thanks in advance. 

[Trey]

Since I don't know the context, I will explain anyway.

 

Leukemic cells can gain certain advantages IF the disease is allowed to progress to the later stages.  The advantages can enable the disease to outsmart the TKI drugs as they morph to allow alternate pathways of survival beyond dependence on tyrosine kinases, so inhibiting those kinases with TKI drugs becomes less effective.  But as long as the CML is kept under control by the TKI drugs the CML does not progress to later stages and therefore the leukemic cells cannot gain those advantages. 

 

You can also read my paper "Genetics of CML Leukemia" here:

http://treyscml.blog...ics-on-cml.html

[Lucas]

Thanks, trey!! it was a generic question, so your answer was what i wanted to hear