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Body overheating without sweating

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#1 gbarrett


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Posted 27 October 2014 - 08:33 AM


I am three years on Tasigna and am having a problem with my body overheating. It happens mostly in the middle of the night but occasionally during daytime. I do not sweat when it happens but my body feels like it will spontaneously combust! As a matter of fact I do not sweat at all anymore, just overheat. Does anyone else experience this? Is it from the med or should I have my doc investigate other causes?

Thanks and good health to all!

#2 hannibellemo


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Posted 27 October 2014 - 05:49 PM

I actually do feel like this and I take Sprycel. I do perspire but I don't tolerate heat well at all. I never have really but it is much worse now.


I remember reading in the LLS literature I was given on CML that heat intolerance was a symptom but I don't think this is caused by CML, especially when it's well controlled.


I didn't experience this during the 9 months I was on Gleevec but I noticed it on the first really warm day with Sprycel, I was in a convertible and I started feeling ill from the heat.


I think it's the drugs.





"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

#3 Trey


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Posted 28 October 2014 - 02:39 PM

These are usually hormone related, and the thyroid can be impacted by TKI drugs.  You may want to have a thyroid function test done. 



#4 rcase13


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Posted 04 February 2015 - 02:28 PM

An old thread but figured I would bring it back. I just had my monthly blood test and my thyroid was high or hyper. I have only been on Tasigna for 4 months but looks like I may have to switch drugs. Has any one else had the TKI mess with the thyroid? I understand there is medication to calm it down, is that an option with Tasigna? I hate to stop Tasigna. My last PCR was 0.06.

10/01/2014 100% Diagnosis (WBC 278k, Blasts 6%, Spleen extended 20cm)

01/02/2015 0.06% Tasigna 600mg
04/08/2015 0.01% Tasigna 600mg
07/01/2015 0.01% Tasigna 600mg
10/05/2015 0.02% Tasigna 600mg
01/04/2016 0.01% Tasigna 600mg
04/04/2016 PCRU Tasigna 600mg
07/18/2016 PCRU Tasigna 600mg
10/12/2016 PCRU Tasigna 600mg
01/09/2017 PCRU Tasigna 600mg
04/12/2017 PCRU Tasigna 600mg
10/16/2017 PCRU Tasigna 600mg
01/15/2018 PCRU Tasigna 600mg


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#5 chrissy778


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Posted 04 February 2015 - 04:33 PM

I am on Gleevec 400mg I did not have my thyroid checked but I do get very hot in the night. Its like a hot flush. I used to get night sweats before diagnosis but I don't have them anymore just these flushes with no sweating. Thanks for sharing

Its never to late to live happily ever after/ Do not squander time; for that's the stuff life is made of

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