Posted 25 September 2014 - 02:49 PM
Not surprised about the low counts. That will likely continue for quite a while, but there is no way to know for certain. This is why high doses are not always the best approach. They can drive the blood counts so low that drug breaks are required. I don't know if that will happen to you, since we are all different. But it is better to stay on a steady dosage than go to a high dosage and have continual drug breaks.
Although - alternating with high/low dose could work. It did for me. I went 20mg / 40mg (following your suggestion by the way) for 3 months which broke the cycle of myelosuppression before returning to just 20mg and great response. Perhaps a 140 one day followed by 70 the next would enable blood counts to recover, but also keep added pressure on the CML. It's just a guessing game at this point. If I lose response (become "detected" again), I will probably go back to 20/40 and not just 20 alone.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"