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3-1/2 Year Results on Gleevec 400mg

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#1 LivingWellWithCML


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Posted 15 August 2014 - 04:07 PM

Hi everyone,


Just got my 3-1/2 year results and I came in at PCRU according to Emory's PCR machine (limit of quantification = 0.0063% IS).  It was unexpected, but obviously a very welcoming result.  If it's actually correct, then I managed to drop at least a full log in 4 months (my April result = 0.05% IS).  Is that even possible?


Some notes on my journey that might be interesting to others:

  • I take a Genistein 125mg supplement each morning with Gleevec 400mg, Vitamin C 500mg & breakfast.  Last year, I tried Genistein for 3 months and my PCR dropped from 0.04% to 0.01%.  Then I stopped it for 3 months and my PCR rose slightly to 0.05%.  Now I've been back on it for ~ 4 months and my PCR dropped below the 0.0063% detection limit.  I find this very interesting!  Perhaps this is an effective combo for my case?
  • My bilirubin level is up a bit to 2.0, which is above the normal range - but obviously nothing to panic about.  My other liver counts (AST/ALT) are fine.  This could be Gleevec, or perhaps just a little too much good wine over the summer.  Do any of you deal with elevated bilirubin?
  • I deal with joint issues (knee tenderness right now; probably cartilage problems), which stinks since I love road cycling and it's really putting a damper on my routine right now.  I asked my specialist about it and he said there's no link between Gleevec and joint cartilage.  Probably just an overuse injury.
  • I am treating my right knee with Voltaren Gel (sparingly).  In looking back at the NSAID/imatinib study, the active ingredient in Voltaren Gel might have a 'positive' impact on the Gleevec uptake into CML cells.  Interesting!  Clearly this is a short-term treatment only, but I guess there's a small chance that it had some bearing on my PCR result.

Overall, I am grateful to still be alive and healthy!  Sending positive vibes to all of you, my CML sisters & brothers...



Dan - Atlanta, GA

CML CP Diagnosed March 2011

Gleevec 400mg

#2 TeddyB


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Posted 16 August 2014 - 04:10 PM

Great news, congrats :)

#3 tiredblood


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Posted 16 August 2014 - 04:36 PM

Congratulations.  That is encouraging to the rest of us too.

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