6 replies to this topic

[CallMeLucky]

http://www.scienceda...40610100257.htm

Interesting article, although I always find it odd when they basically leave you hanging with "stay tuned for more info in the future".  They either have something or they have another theory.  We got lots of theories.

[TeddyB]

Im having my 3 monthly checkup today, good read before i go, thanks

[MichelleH]

Abstract of the article to be published-

http://www.nature.co...eu2014156a.html

[johnny99]

Very interesting! There are also some more articles on the significance of STAT5 in CML. After a little googling I found one abstract that claims curcumin inhibits STAT5 proliferation and expression:

http://www.ncbi.nlm....ubmed/15498113/

Not sure how much to read into all this tho, these research papers are a dime a dozen. But it's certainly encouraging to know a lot people are working on this!

[Trey]

Research into targeting and inhibiting STAT5 (specifically STAT5B) as a means to enhance TKI effectiveness has been ongoing for a number of years.  It shows some degree of promise especially for resistant forms of CML including mutations, but the issue still has many unknowns.  STAT5B is difficult to inhibit.  There is some evidence that Sprycel may inhibit STAT5 to some degree.

http://www.researchg..._Differentially

(Click on the "more" buttons)

Article on STAT5 and CML:

http://bloodjournal....l-text.pdf html

(Click on the "PDF" to see the entire article, if you wish.)

[GerryL]

Another article

http://www.haematolo...t/99/3/417.full

[cousineg]

Another article: STAT5 as a CML target: STATinib therapies?

See also this link: Inhibition of STAT5 in conjunction with standard TKI therapy